General Information of This Target
Target ID
BTDT10270
Target Name
Sodium channel protein type 9 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu-conotoxin GVIIJ Dissociation constant
41 nM
[1- 5]
 Toxin Info    Mu-conotoxin KIIIB Dissociation constant
1.57 μM
[6- 18]
 Toxin Info    Conotoxin im23a Effect . [19]
 Toxin Info    Conotoxin im23b Effect . [19], [20]
 Toxin Info    Beta-toxin Cll2 Inhibition rate . [21], [22], [23]
 Toxin Info    Beta-toxin Cn8 Inhibition rate . [22], [24]
 Toxin Info    Mu-sparatoxin-Hv2 Inhibition rate . [25]
 Toxin Info    Beta-mammal toxin Css2 Inhibition rate . [22- 33]
 Toxin Info    Mu-scoloptoxin(03)-Ssm2a Inhibition rate . [14- 35]
 Toxin Info    Toxin Aah4 Inhibition rate . [36], [37], [38], [39]
 Toxin Info    Toxin Cll1 Inhibition rate . [22- 40]
 Toxin Info    Delta-theraphotoxin-Hm1a Inhibition rate . [41], [42], [43], [44]
 Toxin Info    Omega toxin Ap5 Inhibition rate
16 %
[45]
 Toxin Info    Beta-toxin Tf1a Inhibition rate
17 - 30 %
[46]
 Toxin Info    Omega-theraphotoxin-Pm1a Inhibition rate
17 %
[47], [48]
 Toxin Info    Mu-Sparatoxin-Hp1 Inhibition rate
79 %
[49]
 Toxin Info    Mu-Sparatoxin-Hp2 Inhibition rate
80 %
[49]
 Toxin Info    Mu-theraphotoxin-Pspp1 Inhibition rate
90 %
[50], [51], [52], [53]
 Toxin Info    Delta-conotoxin-like ErVIA Effective concentration 50
2.42 nM
[54]
 Toxin Info    Delta-conotoxin SuVIA Effective concentration 50
2.42 nM
[55]
 Toxin Info    Delta-buthitoxin-Hj2a Effective concentration 50
147.4 nM
[56]
 Toxin Info    Delta/kappa-actitoxin-Avd4a Effective concentration 50
300 nM
[57- 62]
 Toxin Info    Mu/delta-theraphotoxin-Pm2a Effective concentration 50
>10 μM
[63]
 Toxin Info    Alpha-toxin CvIV4 Effective concentration 50
1.34 μM
[64]
 Toxin Info    Alpha-toxin Amm8 Effective concentration 50
1.76 μM
[65- 69]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
˜0.6 nM
[70- 76]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
0.26 nM
[14- 93]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
0.26 - 3 nM
[14- 93]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
0.5 nM
[70- 76]
 Toxin Info    Toxin GTx1-15 IC50
0.58 - 10 nM
[94], [95]
 Toxin Info    Toxin GTx1-15 IC50
0.58 - 10 nM
[14- 96]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
0.8 nM
[70- 76]
 Toxin Info    Mu-theraphotoxin-Pn3a IC50
0.9 - 4.4 nM
[50- 99]
 Toxin Info    Beta-theraphotoxin-Gr1b IC50
1 - 40 nM
[52- 100]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
1 - 1.5 nM
[14- 93]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
2.7 nM
[95- 103]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
2.8 nM
[95- 103]
 Toxin Info    Mu-theraphotoxin-Hsp1a IC50
13 nM
[104]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
15 nM
[14- 93]
 Toxin Info    Beta-theraphotoxin-Ps1a IC50
20 - 610 nM
[95- 105]
 Toxin Info    HwTx-I IC50
25.1 - 630 nM
[52- 116]
 Toxin Info    Mu-theraphotoxin-Hhn1b 1 IC50
48.9 nM
[95- 123]
 Toxin Info    Beta/omega-theraphotoxin-Bp1a IC50
51 - 95 nM
[124]
 Toxin Info    Beta/omega-theraphotoxin-Tp1a IC50
51 - 95 nM
[52- 126]
 Toxin Info    Mu/omega-theraphotoxin-Tap1a IC50
81 - 301 nM
[127]
 Toxin Info    Beta-theraphotoxin-Cm1b IC50
95.5 - 230 nM
[95- 103]
 Toxin Info    Mu-theraphotoxin-Df1a IC50
117 nM
[128]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
129.1 - 5120 nM
[95- 103]
 Toxin Info    Mu-conotoxin SxIIIC IC50
152.2 nM
[129]
 Toxin Info    Beta/mu-theraphotoxin-Pe1b IC50
167 nM
[124]
 Toxin Info    Mu/omega-theraphotoxin-Tap2a IC50
169 - 621 nM
[127]
 Toxin Info    Mu/kappa-theraphotoxin-Ap1a IC50
222 nM
[130]
 Toxin Info    Hainantoxin-III 1 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 2 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 4 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 5 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 6 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 7 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 8 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 9 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 10 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 11 IC50
232 nM
[117- 131]
 Toxin Info    Hainantoxin-III 12 IC50
232 nM
[117- 131]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
250 nM
[14- 93]
 Toxin Info    Mu-theraphotoxin-Pspp1 IC50
254.3 - 260 nM
[50], [51], [52], [53]
 Toxin Info    Mu-theraphotoxin-Pm1a IC50
334 nM
[63]
 Toxin Info    Kappa-theraphotoxin-Ps1a IC50
423 nM
[90- 133]
 Toxin Info    Mu-conotoxin KIIIB IC50
887 nM
[6- 18]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
>1 μM
[70- 76]
 Toxin Info    Kappa-theraphotoxin-Gr2c IC50
0.0136 - 1.03 μM
[52- 100]
 Toxin Info    Beta-theraphotoxin-Gr1a IC50
0.0153 - 1 μM
[52- 134]
 Toxin Info    Mu-theraphotoxin-Pn3a IC50
1.457 μM
[50- 99]
 Toxin Info    Kappa-theraphotoxin-Aa1a IC50
1.528 μM
[130]
 Toxin Info    Sodium channel inhibitor ISTX-I IC50
1.6 μM
[135], [136]
 Toxin Info    MuO-conotoxin MfVIA IC50
2.3 - 5.5 μM
[137], [138]
 Toxin Info    Mu-conotoxin KIIIB IC50
5.4 μM
[6- 18]
 Toxin Info    M-theraphotoxin-Gr1a IC50
7.4 - 14 μM
[94- 149]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 A disulfide tether stabilizes the block of sodium channels by the conotoxin O-GVIIJ. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2758-63. doi: 10.1073/pnas.1324189111. Epub 2014 Feb 4.
Ref 3 Probing the Redox States of Sodium Channel Cysteines at the Binding Site of O-Conotoxin GVIIJ. Biochemistry. 2015 Jun 30;54(25):3911-20. doi: 10.1021/acs.biochem.5b00390. Epub 2015 Jun 18.
Ref 4 - and -subunit composition of voltage-gated sodium channels investigated with -conotoxins and the recently discovered O-conotoxin GVIIJ. J Neurophysiol. 2015 Apr 1;113(7):2289-301. doi: 10.1152/jn.01004.2014. Epub 2015 Jan 28.
Ref 5 Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin O-GVIIJ. J Biol Chem. 2016 Mar 25;291(13):7205-20. doi: 10.1074/jbc.M115.697672. Epub 2016 Jan 27.
Ref 6 Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry. 2005 May 17;44(19):7259-65. doi: 10.1021/bi0473408.
Ref 7 Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. doi: 10.1074/jbc.M704616200. Epub 2007 Aug 27.
Ref 8 Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan;53(1):90-8. doi: 10.1016/j.toxicon.2008.10.017. Epub 2008 Nov 20.
Ref 9 Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin). 2009 Jan-Feb;3(1):32-8. doi: 10.4161/chan.3.1.7500. Epub 2009 Jan 25.
Ref 10 Importance of position 8 in -conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. 2011 Sep;278(18):3408-18. doi: 10.1111/j.1742-4658.2011.08264.x. Epub 2011 Aug 24.
Ref 11 Interactions of key charged residues contributing to selective block of neuronal sodium channels by -conotoxin KIIIA. Mol Pharmacol. 2011 Oct;80(4):573-84. doi: 10.1124/mol.111.073460. Epub 2011 Jun 27.
Ref 12 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 13 Co-expression of Na(V) subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking -conotoxins. Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051.
Ref 14 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
Ref 15 Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9. doi: 10.1021/bi801998a.
Ref 16 Distinct disulfide isomers of -conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry. 2012 Dec 11;51(49):9826-35. doi: 10.1021/bi301256s. Epub 2012 Nov 28.
Ref 17 Molecular basis for pore blockade of human Na(+) channel Na(v)1.2 by the -conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313. doi: 10.1126/science.aaw2999. Epub 2019 Feb 14.
Ref 18 Structural and functional insights into the inhibition of human voltage-gated sodium channels by -conotoxin KIIIA disulfide isomers. J Biol Chem. 2022 Mar;298(3):101728. doi: 10.1016/j.jbc.2022.101728. Epub 2022 Feb 12.
Ref 19 A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily. J Biol Chem. 2012 Apr 27;287(18):14973-83. doi: 10.1074/jbc.M111.334615. Epub 2012 Mar 7.
Ref 20 Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis. Mar Drugs. 2019 Mar 19;17(3):177. doi: 10.3390/md17030177.
Ref 21 Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius. Comp Biochem Physiol B Biochem Mol Biol. 1996 Feb;113(2):331-9. doi: 10.1016/0305-0491(95)02031-4.
Ref 22 Negative-shift activation, current reduction and resurgent currents induced by -toxins from Centruroides scorpions in sodium channels. Toxicon. 2012 Feb;59(2):283-93. doi: 10.1016/j.toxicon.2011.12.003. Epub 2011 Dec 16.
Ref 23 Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms. Toxins (Basel). 2019 Jan 10;11(1):32. doi: 10.3390/toxins11010032.
Ref 24 Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann. J Biochem. 1994 Dec;116(6):1383-91. doi: 10.1093/oxfordjournals.jbchem.a124691.
Ref 25 Purification and Characterization of a Novel Insecticidal Toxin, -sparatoxin-Hv2, from the Venom of the Spider Heteropoda venatoria. Toxins (Basel). 2018 Jun 7;10(6):233. doi: 10.3390/toxins10060233.
Ref 26 Purification and chemical and biological characterizations of seven toxins from the Mexican scorpion, Centruroides suffusus suffusus. J Biol Chem. 1987 Apr 5;262(10):4452-9.
Ref 27 Expression of functional recombinant scorpion beta-neurotoxin Css II in E. coli. Peptides. 2000 Jun;21(6):767-72. doi: 10.1016/s0196-9781(00)00206-0.
Ref 28 Four disulfide-bridged scorpion beta neurotoxin CssII: heterologous expression and proper folding in vitro. Biochim Biophys Acta. 2007 Aug;1770(8):1161-8. doi: 10.1016/j.bbagen.2007.04.006. Epub 2007 May 1.
Ref 29 Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus. Toxicon. 2011 Apr;57(5):739-46. doi: 10.1016/j.toxicon.2011.02.006. Epub 2011 Feb 15.
Ref 30 Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus. Immunol Lett. 2009 Aug 15;125(2):93-9. doi: 10.1016/j.imlet.2009.06.001. Epub 2009 Jun 12.
Ref 31 Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains. J Biol Chem. 2005 Mar 25;280(12):11127-33. doi: 10.1074/jbc.M412552200. Epub 2005 Jan 4.
Ref 32 Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6. Peptides. 2011 Jan;32(1):75-9. doi: 10.1016/j.peptides.2010.11.001. Epub 2010 Nov 13.
Ref 33 Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 sodium channels. Biochim Biophys Acta. 2012 Mar;1824(3):478-87. doi: 10.1016/j.bbapap.2012.01.003. Epub 2012 Jan 11.
Ref 34 Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17534-9. doi: 10.1073/pnas.1306285110. Epub 2013 Sep 30.
Ref 35 Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators. Structure. 2015 Jul 7;23(7):1283-92. doi: 10.1016/j.str.2015.05.003. Epub 2015 Jun 11.
Ref 36 Evidence for a position-specific deletion as an evolutionary link between long- and short-chain scorpion toxins. FEBS Lett. 2001 Apr 13;494(3):246-8. doi: 10.1016/s0014-5793(01)02336-5.
Ref 37 The amino acid sequence of toxin IV from the Androctonus australis scorpion: differing effects of natural mutations in scorpion alpha-toxins on their antigenic and toxic properties. Nat Toxins. 1992;1(1):61-9. doi: 10.1002/nt.2620010112.
Ref 38 Large scale purification of toxins from the venom of the scorpion Androctonus australis Hector. Toxicon. 1986;24(11-12):1131-9. doi: 10.1016/0041-0101(86)90139-x.
Ref 39 AaHIV a sodium channel scorpion toxin inhibits the proliferation of DU145 prostate cancer cells. Biochem Biophys Res Commun. 2020 Jan 8;521(2):340-346. doi: 10.1016/j.bbrc.2019.10.115. Epub 2019 Oct 24.
Ref 40 Primary and NMR three-dimensional structure determination of a novel crustacean toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch. Biochemistry. 1994 Sep 20;33(37):11135-49. doi: 10.1021/bi00203a010.
Ref 41 Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol. 2002 Jul;62(1):48-57. doi: 10.1124/mol.62.1.48.
Ref 42 Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.
Ref 43 A selective Na(V)1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol. 2020 Nov;181:113991. doi: 10.1016/j.bcp.2020.113991. Epub 2020 Apr 23.
Ref 44 Selective Na(V)1.1 activation rescues Dravet syndrome mice from seizures and premature death. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.
Ref 45 Purification and characterization of peptides Ap2, Ap3 and Ap5 (-toxins) from the venom of the Brazilian tarantula Acanthoscurria paulensis. Peptides. 2021 Nov;145:170622. doi: 10.1016/j.peptides.2021.170622. Epub 2021 Aug 5.
Ref 46 Subtype Specificity of -Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels. Toxins (Basel). 2018 Aug 22;10(9):339. doi: 10.3390/toxins10090339.
Ref 47 Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function. Cell Mol Life Sci. 2010 Aug;67(16):2799-813. doi: 10.1007/s00018-010-0359-x. Epub 2010 Apr 6.
Ref 48 Isolation, synthesis and characterization of -TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19.
Ref 49 Molecular Diversity of Peptide Toxins in the Venom of Spider Heteropoda pingtungensis as Revealed by cDNA Library and Transcriptome Sequencing Analysis. Toxins (Basel). 2022 Feb 14;14(2):140. doi: 10.3390/toxins14020140.
Ref 50 Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883.
Ref 51 Corrigendum: Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816.
Ref 52 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 53 Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel). 2019 Aug 22;11(9):484. doi: 10.3390/toxins11090484.
Ref 54 Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5087-92. doi: 10.1073/pnas.1424435112. Epub 2015 Apr 6.
Ref 55 -Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proc Biol Sci. 2015 Jul 22;282(1811):20150817. doi: 10.1098/rspb.2015.0817.
Ref 56 Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel Na(V)1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci. 2019 Nov 25;3(1):119-134. doi: 10.1021/acsptsci.9b00079. eCollection 2020 Feb 14.
Ref 57 Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J Biol Chem. 1998 Mar 20;273(12):6744-9. doi: 10.1074/jbc.273.12.6744.
Ref 58 Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci. 2005 Sep 21;25(38):8735-45. doi: 10.1523/JNEUROSCI.2119-05.2005.
Ref 59 Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. J Neurophysiol. 2012 Jun;107(11):3155-67. doi: 10.1152/jn.00785.2011. Epub 2012 Mar 21.
Ref 60 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 61 A proton nuclear magnetic resonance study of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: sequential and stereospecific resonance assignment and secondary structure. Biochemistry. 1989 Mar 7;28(5):2178-87. doi: 10.1021/bi00431a032.
Ref 62 Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing. Biochemistry. 1989 Mar 7;28(5):2188-98. doi: 10.1021/bi00431a033.
Ref 63 Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na(V)1.7. Biomedicines. 2020 Feb 19;8(2):37. doi: 10.3390/biomedicines8020037.
Ref 64 Isolation and characterization of CvIV4: a pain inducing -scorpion toxin. PLoS One. 2011;6(8):e23520. doi: 10.1371/journal.pone.0023520. Epub 2011 Aug 24.
Ref 65 Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels. Biochem J. 2003 Nov 1;375(Pt 3):551-60. doi: 10.1042/BJ20030688.
Ref 66 Genomic characterisation of the toxin Amm VIII from the scorpion Androctonus mauretanicus mauretanicus. Toxicon. 2006 Apr;47(5):531-6. doi: 10.1016/j.toxicon.2006.01.005. Epub 2006 Mar 14.
Ref 67 New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom. Toxicon. 2008 Apr;51(5):835-52. doi: 10.1016/j.toxicon.2007.12.012. Epub 2007 Dec 17.
Ref 68 Involvement of endogenous opioid system in scorpion toxin-induced antinociception in mice. Neurosci Lett. 2010 Sep 20;482(1):45-50. doi: 10.1016/j.neulet.2010.06.090. Epub 2010 Jul 7.
Ref 69 The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na? channels. Pain. 2013 Aug;154(8):1204-15. doi: 10.1016/j.pain.2013.03.037. Epub 2013 Apr 6.
Ref 70 Isolation and characterization of Jingzhaotoxin-V, a novel neurotoxin from the venom of the spider Chilobrachys jingzhao. Toxicon. 2007 Mar 1;49(3):388-99. doi: 10.1016/j.toxicon.2006.10.012. Epub 2006 Nov 6.
Ref 71 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 72 [Inhibition of Jingzhaotoxin-V on Kv4.3 channel]. Sheng Li Xue Bao. 2010 Jun 25;62(3):255-60.
Ref 73 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
Ref 74 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 75 Molecular surface of JZTX-V (-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel). 2014 Jul 23;6(7):2177-93. doi: 10.3390/toxins6072177.
Ref 76 Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V. PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018.
Ref 77 Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry. 2002 Dec 17;41(50):14734-47. doi: 10.1021/bi026546a.
Ref 78 Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation. J Biol Chem. 2007 Apr 27;282(17):12687-97. doi: 10.1074/jbc.M610462200. Epub 2007 Mar 5.
Ref 79 ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels. Toxicon. 2007 Feb;49(2):194-201. doi: 10.1016/j.toxicon.2006.09.014. Epub 2006 Sep 27.
Ref 80 Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol. 2008 Mar;73(3):1020-8. doi: 10.1124/mol.107.041046. Epub 2007 Dec 21.
Ref 81 ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol. 2008 Nov;74(5):1476-84. doi: 10.1124/mol.108.047670. Epub 2008 Aug 26.
Ref 82 Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. Toxicon. 2008 Sep 1;52(3):489-500. doi: 10.1016/j.toxicon.2008.06.023. Epub 2008 Jul 9.
Ref 83 The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation. Mol Pharmacol. 2010 Dec;78(6):1124-34. doi: 10.1124/mol.110.066332. Epub 2010 Sep 20.
Ref 84 Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII. Toxicon. 2010 Sep 15;56(4):624-36. doi: 10.1016/j.toxicon.2010.06.009. Epub 2010 Jun 23.
Ref 85 Crystallographic insights into sodium-channel modulation by the 4 subunit. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi: 10.1073/pnas.1314557110. Epub 2013 Dec 2.
Ref 86 Block of T-type calcium channels by protoxins I and II. Mol Brain. 2014 May 9;7:36. doi: 10.1186/1756-6606-7-36.
Ref 87 High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots. Int J Pept. 2015;2015:537508. doi: 10.1155/2015/537508. Epub 2015 Dec 30.
Ref 88 Binary architecture of the Nav1.2-2 signaling complex. Elife. 2016 Feb 19;5:e10960. doi: 10.7554/eLife.10960.
Ref 89 Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor. Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662.
Ref 90 Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. J Med Chem. 2014 Aug 14;57(15):6623-31. doi: 10.1021/jm500687u. Epub 2014 Jul 24.
Ref 91 Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.
Ref 92 Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17.
Ref 93 Structures of human Na(v)1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 Mar 22;363(6433):1303-1308. doi: 10.1126/science.aaw2493. Epub 2019 Feb 14.
Ref 94 Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 2011 Sep 1;58(3):265-76. doi: 10.1016/j.toxicon.2011.06.006. Epub 2011 Jun 28.
Ref 95 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 96 Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3):78. doi: 10.3390/toxins8030078.
Ref 97 Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain. 2019 Aug;160(8):1766-1780. doi: 10.1097/j.pain.0000000000001567.
Ref 98 Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels. Front Pharmacol. 2021 Jan 28;11:633679. doi: 10.3389/fphar.2020.633679. eCollection 2020.
Ref 99 -Theraphotoxin Pn3a inhibition of Ca(V)3.3 channels reveals a novel isoform-selective drug binding site. Elife. 2022 Jul 20;11:e74040. doi: 10.7554/eLife.74040.
Ref 100 Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. doi: 10.1074/jbc.M109.054718. Epub 2009 Dec 2.
Ref 101 Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29. doi: 10.1124/mol.105.015941. Epub 2005 Nov 2.
Ref 102 Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J Biol Chem. 2016 Jul 1;291(27):13974-13986. doi: 10.1074/jbc.M116.725978. Epub 2016 Apr 22.
Ref 103 Discovery and mode of action of a novel analgesic -toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.
Ref 104 Fluorescence Imaging of Peripheral Nerves by a Na(v)1.7-Targeted Inhibitor Cystine Knot Peptide. Bioconjug Chem. 2019 Nov 20;30(11):2879-2888. doi: 10.1021/acs.bioconjchem.9b00612. Epub 2019 Nov 8.
Ref 105 Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins. Toxins (Basel). 2017 Aug 12;9(8):248. doi: 10.3390/toxins9080248.
Ref 106 cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena. Toxicon. 2003 Dec;42(7):715-23. doi: 10.1016/j.toxicon.2003.08.007.
Ref 107 Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena. Toxicon. 1993 Aug;31(8):969-78. doi: 10.1016/0041-0101(93)90256-i.
Ref 108 Assignment of the three disulfide bridges of huwentoxin-I, a neurotoxin from the spider selenocosmia huwena. J Protein Chem. 1993 Dec;12(6):735-40. doi: 10.1007/BF01024931.
Ref 109 Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena. Toxicon. 1997 Jan;35(1):39-45. doi: 10.1016/s0041-0101(96)00072-4.
Ref 110 [Chemical synthesis and characterization of R20A-HWTX-I, a mutant of huwentoxin-I with single residue replacement]. Sheng Wu Gong Cheng Xue Bao. 2000 Jul;16(4):490-4.
Ref 111 The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena. Toxicon. 2000 Sep;38(9):1237-46. doi: 10.1016/s0041-0101(99)00224-x.
Ref 112 The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study. Toxicon. 2001 Apr;39(4):491-8. doi: 10.1016/s0041-0101(00)00150-1.
Ref 113 Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats. Toxicon. 2005 Jan;45(1):15-20. doi: 10.1016/j.toxicon.2004.08.018.
Ref 114 The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun. 2007 Jun 8;357(3):579-83. doi: 10.1016/j.bbrc.2007.02.168. Epub 2007 Apr 9.
Ref 115 Functional expression of spider neurotoxic peptide huwentoxin-I in E. coli. PLoS One. 2011;6(6):e21608. doi: 10.1371/journal.pone.0021608. Epub 2011 Jun 23.
Ref 116 Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution. J Protein Chem. 1997 Aug;16(6):565-74. doi: 10.1023/a:1026314722607.
Ref 117 Molecular diversification of peptide toxins from the tarantula Haplopelma hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses. J Proteome Res. 2010 May 7;9(5):2550-64. doi: 10.1021/pr1000016.
Ref 118 Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana. Cell Mol Life Sci. 2003 May;60(5):972-8. doi: 10.1007/s00018-003-2354-x.
Ref 119 Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol. 2003 Sep 5;477(1):1-7. doi: 10.1016/s0014-2999(03)02190-3.
Ref 120 Inhibition of sodium channels in rat dorsal root ganglion neurons by Hainantoxin-IV, a novel spider toxin. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Jan;35(1):82-5.
Ref 121 Synthesis and oxidative refolding of hainantoxin-IV. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jul;34(4):516-9.
Ref 122 [Solid-phase synthesis and biological characterization of S12A-HNTX-IV and R29A-HNTX-IV: two mutants of hainantoxin-IV]. Sheng Wu Gong Cheng Xue Bao. 2005 Jan;21(1):92-6.
Ref 123 Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers. J Biol Chem. 2004 Sep 3;279(36):37734-40. doi: 10.1074/jbc.M405765200. Epub 2004 Jun 16.
Ref 124 Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na(V)1.7. Biochem Pharmacol. 2020 Nov;181:114080. doi: 10.1016/j.bcp.2020.114080. Epub 2020 Jun 6.
Ref 125 Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ Channels Cav3.1 and Cav3.2. J Pharmacol Sci. 2010;112(4):452-8. doi: 10.1254/jphs.09356fp. Epub 2010 Mar 30.
Ref 126 A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.
Ref 127 A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain. 2021 Feb 1;162(2):569-581. doi: 10.1097/j.pain.0000000000002041.
Ref 128 Modulatory features of the novel spider toxin -TRTX-Df1a isolated from the venom of the spider Davus fasciatus. Br J Pharmacol. 2017 Aug;174(15):2528-2544. doi: 10.1111/bph.13865. Epub 2017 Jun 27.
Ref 129 Discovery, Pharmacological Characterisation and NMR Structure of the Novel -Conotoxin SxIIIC, a Potent and Irreversible Na(V) Channel Inhibitor. Biomedicines. 2020 Oct 2;8(10):391. doi: 10.3390/biomedicines8100391.
Ref 130 Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25.
Ref 131 Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana. J Biol Chem. 2013 Jul 12;288(28):20392-403. doi: 10.1074/jbc.M112.426627. Epub 2013 May 23.
Ref 132 Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol. 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283.
Ref 133 Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004 May;13(5):1197-208. doi: 10.1110/ps.03584304.
Ref 134 Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels. Toxicon. 2007 Jul;50(1):65-74. doi: 10.1016/j.toxicon.2007.02.015. Epub 2007 Mar 3.
Ref 135 An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochem Mol Biol. 2006 Feb;36(2):111-29. doi: 10.1016/j.ibmb.2005.11.005. Epub 2005 Dec 20.
Ref 136 A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds. Sci Rep. 2016 Jul 13;6:29691. doi: 10.1038/srep29691.
Ref 137 Isolation, characterization and total regioselective synthesis of the novel O-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem Pharmacol. 2012 Aug 15;84(4):540-8. doi: 10.1016/j.bcp.2012.05.008. Epub 2012 May 16.
Ref 138 Development of a O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J Biol Chem. 2016 May 27;291(22):11829-42. doi: 10.1074/jbc.M116.721662. Epub 2016 Mar 29.
Ref 139 cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon. 2003 Sep;42(3):263-74. doi: 10.1016/s0041-0101(03)00141-7.
Ref 140 Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583-98. doi: 10.1085/jgp.115.5.583.
Ref 141 Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem. 2002 Sep 13;277(37):34443-50. doi: 10.1074/jbc.M202715200. Epub 2002 Jun 24.
Ref 142 Tarantula peptide inhibits atrial fibrillation. Nature. 2001 Jan 4;409(6816):35-6. doi: 10.1038/35051165.
Ref 143 Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry. 2004 Aug 10;43(31):10071-9. doi: 10.1021/bi049463y.
Ref 144 Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004 Jul 8;430(6996):235-40. doi: 10.1038/nature02743.
Ref 145 Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-8. doi: 10.1016/j.bbrc.2005.12.046. Epub 2005 Dec 19.
Ref 146 Effects of tarantula toxin GsMTx4 on the membrane motor of outer hair cells. Neurosci Lett. 2006 Aug 14;404(1-2):213-6. doi: 10.1016/j.neulet.2006.05.059. Epub 2006 Jun 22.
Ref 147 Molecular dynamics simulations of a stretch-activated channel inhibitor GsMTx4 with lipid membranes: two binding modes and effects of lipid structure. Biophys J. 2007 Jun 15;92(12):4233-43. doi: 10.1529/biophysj.106.101071. Epub 2007 Mar 23.
Ref 148 Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers?. Biophys J. 2007 Aug 15;93(4):L20-2. doi: 10.1529/biophysj.107.112375. Epub 2007 Jun 15.
Ref 149 Fast desensitization of acetylcholine receptors induced by a spider toxin. Channels (Austin). 2021 Dec;15(1):507-515. doi: 10.1080/19336950.2021.1961459.
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