Peptide Information

General Information of This Peptide
Peptide ID
BTDP008681
Peptide Name
Delta-theraphotoxin-Hm1a
Symonym
Heteroscodratoxin-1; Kappa-theraphotoxin-Hm1a
Species
Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
Uniprot Name
TX1A_HETMC
Alphafold ID
P60992
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2N6O
Sequence
ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
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Sequence Length
35
Mass (Da)
4003
Sequence Removed Signal Peptide
ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
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Disulfide Bond
2-16;9-21;15-28
PDB ID
2N6O
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Heteroscodra
Species: Heteroscodra maculata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Inhibition rate .
1 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.2 Inhibition rate .
50 nM
 . [1], [2], [3], [4]
 Target Info    Nav1.4 Inhibition rate .
1 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.5 Inhibition rate .
1 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.6 Inhibition rate .
1 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.7 Inhibition rate .
1 μM
 . [1], [2], [3], [4]
 Target Info    Kv1.6 Inhibition rate
1 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.5 Inhibition rate
2 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.3 Inhibition rate
3 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.2 Inhibition rate
4 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.4 Inhibition rate
4 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv3.4 Inhibition rate
4 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv7.1 Inhibition rate
8 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.1 Inhibition rate
12 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv2.2 Inhibition rate
19.7 %
100 nM
 . [1], [2], [3], [4]
 Target Info    Kv2.2 Inhibition rate
19.7 %
100 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv2.1 Inhibition rate
23 %
100 nM
 . [1], [2], [3], [4]
 Target Info    Kv2.1 Inhibition rate
23 %
100 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv4.2 Inhibition rate
39 %
300 nM
 . [1], [2], [3], [4]
 Target Info    Kv4.2 Inhibition rate
39 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv4.3 Inhibition rate
43 %
300 nM
 . [1], [2], [3], [4]
 Target Info    Kv4.3 Inhibition rate
43 %
300 nM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv2.2 Inhibition rate
51 %
300 nM
 . [1], [2], [3], [4]
 Target Info    Nav1.3 Effective concentration 50
220 nM
 . . [1], [2], [3], [4]
 Target Info    Nav1.2 Effective concentration 50
236 nM
 . . [1], [2], [3], [4]
 Target Info    Kv4.1 IC50
280 nM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv4.1 IC50
280 nM
 . . [1], [2], [3], [4]
References
Ref 1 Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol. 2002 Jul;62(1):48-57. doi: 10.1124/mol.62.1.48.
Ref 2 Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.
Ref 3 A selective Na(V)1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol. 2020 Nov;181:113991. doi: 10.1016/j.bcp.2020.113991. Epub 2020 Apr 23.
Ref 4 Selective Na(V)1.1 activation rescues Dravet syndrome mice from seizures and premature death. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.
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