Peptide Information

General Information of This Peptide
Peptide ID
BTDP005375
Peptide Name
Mu/omega-theraphotoxin-Tap1a
Symonym
Mu/omega-TRTX-Tap1a
Species
Theraphosa apophysis (Goliath pinkfoot tarantula) (Pseudotheraphosa apophysis)
Uniprot Name
TAP1A_THEAO
Alphafold ID
P0DQO3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DQO3
Sequence
DDCLGMFSSCDPNNDKCCPNRKCSRKDQWCKYQLW
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Sequence Length
35
Mass (Da)
4189
Sequence Removed Signal Peptide
DDCLGMFSSCDPNNDKCCPNRKCSRKDQWCKYQLW
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Disulfide Bond
3-18;10-23;17-30
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Theraphosa
Species: Theraphosa apophysis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.1 IC50
81 - 301 nM
 . . [1]
 Target Info    Nav1.2 IC50
81 - 301 nM
 . . [1]
 Target Info    Nav1.3 IC50
81 - 301 nM
 . . [1]
 Target Info    Nav1.6 IC50
81 - 301 nM
 . . [1]
 Target Info    Nav1.7 IC50
81 - 301 nM
 . . [1]
 Target Info    Cav3.1 IC50
81 - 301 nM
 . . [1]
 Target Info    Cav3.2 IC50
1.233 μM
 . . [1]
References
Ref 1 A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain. 2021 Feb 1;162(2):569-581. doi: 10.1097/j.pain.0000000000002041.
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