Peptide Information

General Information of This Peptide
Peptide ID
BTDP005372
Peptide Name
Mu-theraphotoxin-Pm1a
Symonym
Mu-TRTX-Pm1a
Species
Poecilotheria metallica (Metallic blue ornamental tree spider)
Uniprot Name
TX621_POEME
Alphafold ID
P0DQO0
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQO0
Sequence
GGCRYFLGGCSEHSDCCEHLRCKMGLNYCAWDGTF
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Sequence Length
35
Mass (Da)
3920
Sequence Removed Signal Peptide
GGCRYFLGGCSEHSDCCEHLRCKMGLNYCAWDGTF
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Disulfide Bond
3-17;10-22;16-29
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Poecilotheria
Species: Poecilotheria metallica
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Inhibition rate
21 %
10 μM
 . [1]
 Target Info    Nav1.7 IC50
334 nM
 . . [1]
References
Ref 1 Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na(V)1.7. Biomedicines. 2020 Feb 19;8(2):37. doi: 10.3390/biomedicines8020037.
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