Peptide Information

General Information of This Peptide
Peptide ID
BTDP004941
Peptide Name
Toxin GTx1-15
Symonym
Beta/omega-theraphotoxin-Gr2a; Toxin GpTx-1
Species
Grammostola porteri (Tarantula spider) (Lasiodora porteri)
Uniprot Name
TX15_GRAPO
Alphafold ID
P0DL72
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6MK5
Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Sequence Length
34
Mass (Da)
4081
Sequence Removed Signal Peptide
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Disulfide Bond
2-17;9-23;16-30
PDB ID
6MK5
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola porteri
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav3.1 Inhibition rate
30 %
9.8 nM
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.7 IC50
0.58 - 10 nM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.2 IC50
5 - 128 nM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.1 IC50
6 nM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.6 IC50
17 - 20.1 nM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.3 IC50
20.3 - 170 nM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.8 IC50
0.068 - 12.2 μM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.5 IC50
0.14 - >10 μM
 .
Inhibition of the peak current
 [1], [2]
 Target Info    Nav1.4 IC50
0.2 - >10 μM
 .
Inhibition of the peak current
 [1], [2]
References
Ref 1 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
Ref 2 Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016 Mar 17;8(3):78. doi: 10.3390/toxins8030078.
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