Peptide Information

General Information of This Peptide
Peptide ID
BTDP008368
Peptide Name
Delta/kappa-actitoxin-Avd4a
Symonym
Antihypertensive protein BDS-1; Blood depressing substance I
Species
Anemonia sulcata (Mediterranean snakelocks sea anemone)
Uniprot Name
BDS1_ANESU
Alphafold ID
P11494
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1BDS
Sequence
AAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
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Sequence Length
43
Mass (Da)
4714
Sequence Removed Signal Peptide
AAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
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Disulfide Bond
4-39;6-32;22-40
PDB ID
1BDS , 2BDS
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anemonia
Species: Anemonia sulcata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv Dissociation constant
12 nM
 .
Modifier
 [1- 6]
 Target Info    Kir2.2 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kir1.1 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kir2.1 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.1 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.5 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv2.1 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv2.2 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv3.2 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv3.3 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv4.2 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv4.3 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.3 Inhibition rate
17 %
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.2 Inhibition rate
19 %
100 μM
Modifier
 [1- 6]
 Target Info    Kv3.1 Inhibition rate
22 %
100 μM
Modifier
 [1- 6]
 Target Info    Kv3.1 Inhibition rate
45 %
 .
When tested at a voltage of +40 mV
[1- 6]
 Target Info    Kv3.2 Inhibition rate
48 %
 .
When tested at a voltage of +40 mV
[1- 6]
 Target Info    Kv3.4 Inhibition rate
56 %
 .
When tested at a voltage of +40 mV
[1- 6]
 Target Info    Kv3.4 Inhibition rate
65 %
100 nM
Modifier
 [1- 6]
 Target Info    Kv3.4 Inhibition rate
94 %
100 μM
Modifier
 [1- 6]
 Target Info    Nav1.7 Effective concentration 50
3 nM
 .
When tested at a voltage of +40 mV
[1- 6]
 Target Info    Nav1.7 Effective concentration 50
300 nM
 .
When tested at a voltage of +40 mV
[1- 6]
 Target Info    Kv3.4 IC50
47 nM
 .
Modifier
 [1- 6]
References
Ref 1 Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J Biol Chem. 1998 Mar 20;273(12):6744-9. doi: 10.1074/jbc.273.12.6744.
Ref 2 Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci. 2005 Sep 21;25(38):8735-45. doi: 10.1523/JNEUROSCI.2119-05.2005.
Ref 3 Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. J Neurophysiol. 2012 Jun;107(11):3155-67. doi: 10.1152/jn.00785.2011. Epub 2012 Mar 21.
Ref 4 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 5 A proton nuclear magnetic resonance study of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: sequential and stereospecific resonance assignment and secondary structure. Biochemistry. 1989 Mar 7;28(5):2178-87. doi: 10.1021/bi00431a032.
Ref 6 Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing. Biochemistry. 1989 Mar 7;28(5):2188-98. doi: 10.1021/bi00431a033.
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