Peptide Information

General Information of This Peptide
Peptide ID
BTDP005990
Peptide Name
Toxin Cll1
Symonym
Cll toxin 1; Crustacean toxin 1
Species
Centruroides limpidus (Mexican scorpion)
Uniprot Name
SCX1_CENLI
Alphafold ID
P45667
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P45667
Sequence
KEGYLVNKSTGCKYGCFWLGKNENCDKECKAKNQGGSYGYCYSFACWCEGLPESTPTYPL
PNKSCS
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Sequence Length
66
Mass (Da)
7338
Sequence Removed Signal Peptide
KEGYLVNKSTGCKYGCFWLGKNENCDKECKAKNQGGSYGYCYSFACWCEGLPESTPTYPL
PNKSCS
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Disulfide Bond
12-65;16-41;25-46;29-48
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides limpidus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Inhibition rate .
560 nM
 . [1], [2], [3]
 Target Info    Nav1.6 IC50
44.9 nM
 . . [1], [2], [3]
References
Ref 1 Primary and NMR three-dimensional structure determination of a novel crustacean toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch. Biochemistry. 1994 Sep 20;33(37):11135-49. doi: 10.1021/bi00203a010.
Ref 2 Negative-shift activation, current reduction and resurgent currents induced by -toxins from Centruroides scorpions in sodium channels. Toxicon. 2012 Feb;59(2):283-93. doi: 10.1016/j.toxicon.2011.12.003. Epub 2011 Dec 16.
Ref 3 Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms. Toxins (Basel). 2019 Jan 10;11(1):32. doi: 10.3390/toxins11010032.
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