Peptide Information

General Information of This Peptide
Peptide ID
BTDP001796
Peptide Name
Mu-conotoxin SxIIIC
Species
Conus striolatus (Cone snail)
Uniprot Name
CM3C_CONSR
Alphafold ID
A0A7M4DUE8
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6X8R
Sequence
RGCCNGRGGCSSRWCRDHARCC
   Click to Show/Hide
Sequence Length
22
Mass (Da)
2444
Sequence Removed Signal Peptide
RGCCNGRGGCSSRWCRDHARCC
   Click to Show/Hide
Disulfide Bond
3-15;4-21;10-22
PDB ID
6X8R
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus striolatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.5 Inhibition rate .
1 μM
 . [1]
 Target Info    Nav1.8 Inhibition rate .
1 μM
 . [1]
 Target Info    Nav1.4 IC50
15.11 nM
 . . [1]
 Target Info    Nav1.3 IC50
89.4 nM
 . . [1]
 Target Info    Nav1.6 IC50
124.9 nM
 . . [1]
 Target Info    Nav1.1 IC50
132 nM
 . . [1]
 Target Info    Nav1.7 IC50
152.2 nM
 . . [1]
 Target Info    Nav1.2 IC50
363.8 nM
 . . [1]
References
Ref 1 Discovery, Pharmacological Characterisation and NMR Structure of the Novel -Conotoxin SxIIIC, a Potent and Irreversible Na(V) Channel Inhibitor. Biomedicines. 2020 Oct 2;8(10):391. doi: 10.3390/biomedicines8100391.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.