Peptide Information

General Information of This Peptide
Peptide ID
BTDP005371
Peptide Name
Delta-buthitoxin-Hj2a
Symonym
Delta-BUTX-Hj2a
Species
Hottentotta judaicus (Black scorpion) (Buthotus judaicus)
Uniprot Name
DEL2A_HOTJU
Alphafold ID
P0DQN9
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQN9
Sequence
GRDAYIADDKNCVYTCAKNSYCNNECTKNGAESGYCQWLGKYGNGCWCKNLPDKVPIRIP
GPCR
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Sequence Length
64
Mass (Da)
7127
Sequence Removed Signal Peptide
GRDAYIADDKNCVYTCAKNSYCNNECTKNGAESGYCQWLGKYGNGCWCKNLPDKVPIRIP
GPCR
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Disulfide Bond
12-63;16-36;22-46;26-48
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Hottentotta
Species: Hottentotta judaicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Effective concentration 50
32 nM
 . . [1]
 Target Info    Nav1.6 Effective concentration 50
46.3 nM
 . . [1]
 Target Info    Nav1.1 Effective concentration 50
52.8 nM
 . . [1]
 Target Info    Nav1.5 Effective concentration 50
116.7 nM
 . . [1]
 Target Info    Nav1.7 Effective concentration 50
147.4 nM
 . . [1]
References
Ref 1 Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel Na(V)1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci. 2019 Nov 25;3(1):119-134. doi: 10.1021/acsptsci.9b00079. eCollection 2020 Feb 14.
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