Peptide Information

General Information of This Peptide
Peptide ID
BTDP005373
Peptide Name
Mu/delta-theraphotoxin-Pm2a
Symonym
Delta/mu-theraphotoxin-Pm2a
Species
Poecilotheria metallica (Metallic blue ornamental tree spider)
Uniprot Name
PME2A_POEME
Alphafold ID
P0DQO1
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQO1
Sequence
GCTKFMGSCKTDADCCEHLECYKYKWCGWDGTF
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Sequence Length
33
Mass (Da)
3817
Sequence Removed Signal Peptide
GCTKFMGSCKTDADCCEHLECYKYKWCGWDGTF
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Disulfide Bond
2-16;9-21;15-27
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Poecilotheria
Species: Poecilotheria metallica
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Inhibition rate
22 %
10 μM
 . [1]
 Target Info    Nav1.7 Effective concentration 50
>10 μM
 . . [1]
References
Ref 1 Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na(V)1.7. Biomedicines. 2020 Feb 19;8(2):37. doi: 10.3390/biomedicines8020037.
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