Peptide Information

General Information of This Peptide
Peptide ID
BTDP005983
Peptide Name
Toxin Aah4
Symonym
AaH IV; Neurotoxin 4; Neurotoxin IV
Species
Androctonus australis (Sahara scorpion)
Uniprot Name
SCX4_ANDAU
Alphafold ID
P45658
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P45658
Sequence
MNYLIMFSLALLLVIGVESGRDGYIVDSKNCVYHCYPPCDGLCKKNGAKSGSCGFLVPSG
LACWCNDLPENVPIKDPSDDCHKR
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Sequence Length
84
Mass (Da)
9157
Signal Sequence
MNYLIMFSLALLLVIGVES
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Sequence Removed Signal Peptide
GRDGYIVDSKNCVYHCYPPCDGLCKKNGAKSGSCGFLVPSGLACWCNDLPENVPIKDPSD
DCHKR
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Disulfide Bond
31-81;35-53;39-63;43-65
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus australis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Inhibition rate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.2 Inhibition rate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.4 Inhibition rate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.5 Inhibition rate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.7 Inhibition rate .
5 μM
 . [1], [2], [3], [4]
 Target Info    Nav1.6 IC50
15 μM
 . . [1], [2], [3], [4]
References
Ref 1 Evidence for a position-specific deletion as an evolutionary link between long- and short-chain scorpion toxins. FEBS Lett. 2001 Apr 13;494(3):246-8. doi: 10.1016/s0014-5793(01)02336-5.
Ref 2 The amino acid sequence of toxin IV from the Androctonus australis scorpion: differing effects of natural mutations in scorpion alpha-toxins on their antigenic and toxic properties. Nat Toxins. 1992;1(1):61-9. doi: 10.1002/nt.2620010112.
Ref 3 Large scale purification of toxins from the venom of the scorpion Androctonus australis Hector. Toxicon. 1986;24(11-12):1131-9. doi: 10.1016/0041-0101(86)90139-x.
Ref 4 AaHIV a sodium channel scorpion toxin inhibits the proliferation of DU145 prostate cancer cells. Biochem Biophys Res Commun. 2020 Jan 8;521(2):340-346. doi: 10.1016/j.bbrc.2019.10.115. Epub 2019 Oct 24.
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