Peptide Information

General Information of This Peptide
Peptide ID
BTDP008648
Peptide Name
Mu/kappa-theraphotoxin-Ap1a
Species
Avicularia purpurea (Ecuadorian purple pinktoe tarantula)
Uniprot Name
NTA_AVIPU
Alphafold ID
P0DQJ6
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DQJ6
Sequence
GDCHKFWGWCRDEPDPCCEHLTCSTKHGWCVWDGSF
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Sequence Length
36
Mass (Da)
4230
Sequence Removed Signal Peptide
GDCHKFWGWCRDEPDPCCEHLTCSTKHGWCVWDGSF
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Disulfide Bond
3-18;10-23;17-30
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Avicularia
Species: Avicularia purpurea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
222 nM
 .
Blocker
 [1]
 Target Info    Kv11.1 IC50
236 nM
 .
Blocker
 [1]
 Target Info    Kv10 IC50
236 nM
 .
Blocker
 [1]
 Target Info    Nav1.2 IC50
519 nM
 .
Blocker
 [1]
 Target Info    Nav1.5 IC50
2.565 μM
 .
Blocker
 [1]
 Target Info    Kv11 IC50
8.197 μM
 .
Blocker
 [1]
 Target Info    Kv11.1 IC50
8.197 μM
 .
Blocker
 [1]
References
Ref 1 Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25.
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