Peptide Information

General Information of This Peptide
Peptide ID
BTDP004956
Peptide Name
MuO-conotoxin MfVIA
Species
Conus magnificus (Magnificent cone) (Darioconus magnificus)
Uniprot Name
CO6A_CONMF
Alphafold ID
P0DM15
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2N7F
Sequence
RDCQEKWEYCIVPILGFVYCCPGLICGPFVCV
   Click to Show/Hide
Sequence Length
32
Mass (Da)
3654
Sequence Removed Signal Peptide
RDCQEKWEYCIVPILGFVYCCPGLICGPFVCV
   Click to Show/Hide
Disulfide Bond
3-21;10-26;20-31
PDB ID
2N7F
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus magnificus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 IC50
81 nM
 . . [1], [2]
 Target Info    Nav1.8 IC50
96 - 529 nM
 . . [1], [2]
 Target Info    Nav1.5 IC50
0.431 - 3.9 μM
 . . [1], [2]
 Target Info    Nav1.6 IC50
1.2 - 4.6 μM
 . . [1], [2]
 Target Info    Nav1.3 IC50
2.2 μM
 . . [1], [2]
 Target Info    Nav1.7 IC50
2.3 - 5.5 μM
 . . [1], [2]
 Target Info    Nav1.1 IC50
3.3 μM
 . . [1], [2]
 Target Info    Nav1.2 IC50
5.1 - 6.3 μM
 . . [1], [2]
References
Ref 1 Isolation, characterization and total regioselective synthesis of the novel O-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem Pharmacol. 2012 Aug 15;84(4):540-8. doi: 10.1016/j.bcp.2012.05.008. Epub 2012 May 16.
Ref 2 Development of a O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J Biol Chem. 2016 May 27;291(22):11829-42. doi: 10.1074/jbc.M116.721662. Epub 2016 Mar 29.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.