Peptide Information

General Information of This Peptide
Peptide ID
BTDP007569
Peptide Name
Alpha-toxin Amm8
Symonym
Alpha-anatoxin Amm VIII; Neurotoxin 8; P4
Species
Androctonus mauritanicus mauritanicus (Scorpion)
Uniprot Name
SCX8_ANDMA
Alphafold ID
Q7YXD3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: Q7YXD3
Sequence
MNYLVMISLALLFMTGVESLKDGYIVNDINCTYFCGRNAYCNELCIKLKGESGYCQWASP
YGNSCYCYKLPDHVRTKGPGRCNDR
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Sequence Length
85
Mass (Da)
9654
Signal Sequence
MNYLVMISLALLFMTGVES
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Sequence Removed Signal Peptide
LKDGYIVNDINCTYFCGRNAYCNELCIKLKGESGYCQWASPYGNSCYCYKLPDHVRTKGP
GRCNDR
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Disulfide Bond
31-82;35-55;41-65;45-67
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus mauritanicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 Effective concentration 50
29 nM
 . . [1- 5]
 Target Info    Nav1.4 Effective concentration 50
416 nM
 .
Skeletal muscle
 [1- 5]
 Target Info    Nav1.7 Effective concentration 50
1.76 μM
 . . [1- 5]
References
Ref 1 Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels. Biochem J. 2003 Nov 1;375(Pt 3):551-60. doi: 10.1042/BJ20030688.
Ref 2 Genomic characterisation of the toxin Amm VIII from the scorpion Androctonus mauretanicus mauretanicus. Toxicon. 2006 Apr;47(5):531-6. doi: 10.1016/j.toxicon.2006.01.005. Epub 2006 Mar 14.
Ref 3 New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom. Toxicon. 2008 Apr;51(5):835-52. doi: 10.1016/j.toxicon.2007.12.012. Epub 2007 Dec 17.
Ref 4 Involvement of endogenous opioid system in scorpion toxin-induced antinociception in mice. Neurosci Lett. 2010 Sep 20;482(1):45-50. doi: 10.1016/j.neulet.2010.06.090. Epub 2010 Jul 7.
Ref 5 The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na? channels. Pain. 2013 Aug;154(8):1204-15. doi: 10.1016/j.pain.2013.03.037. Epub 2013 Apr 6.
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