Peptide Information

General Information of This Peptide
Peptide ID
BTDP008348
Peptide Name
Beta/kappa-theraphotoxin-Cg2a
Symonym
Beta-theraphotoxin-Cj2a; Jingzhaotoxin-5; Jingzhaotoxin-V; Peptide F8-15.73
Species
Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
Uniprot Name
JZTX5_CHIGU
Alphafold ID
Q2PAY4
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6CGW
Sequence
MKASVFAVILGLVVLCACSFAEDEQDQFVSPNELLKSMFVESRHEFTPEVEGRYCQKWMW
TCDSKRACCEGLRCKLWCRKIIG
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Sequence Length
83
Mass (Da)
9586
Signal Sequence
MKASVFAVILGLVVLCACSFA
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Sequence Removed Signal Peptide
EDEQDQFVSPNELLKSMFVESRHEFTPEVEGRYCQKWMWTCDSKRACCEGLRCKLWCRKI
IG
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Disulfide Bond
55-69;62-74;68-78
PDB ID
6CGW , 6CHC , 6CNU
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Chilobrachys
Species: Chilobrachys guangxiensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv2.1 Dissociation constant
14.3 μM
 .
Modifier
 [1- 6]
 Target Info    Kv1.2 Inhibition rate . . . [1- 7]
 Target Info    Kv1.2 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.3 Inhibition rate . . . [1- 7]
 Target Info    Kv1.3 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv1.4 Inhibition rate . . . [1- 7]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Modifier
 [1- 6]
 Target Info    Kv4.1 Inhibition rate
25 %
5 μM
Modifier
 [1- 6]
 Target Info    Kv2.1 Inhibition rate
35 %
5 μM
Modifier
 [1- 6]
 Target Info    Kv4.2 Inhibition rate
90 %
5 μM
Modifier
 [1- 6]
 Target Info    Nav1.7 IC50
˜0.6 nM
 . . [1- 7]
 Target Info    Nav1.7 IC50
0.5 nM
 . . [1- 7]
 Target Info    Nav1.7 IC50
0.8 nM
 . . [1- 7]
 Target Info    Nav1.4 IC50
2.2 - 159 nM
 . . [1- 7]
 Target Info    Kv4.3 IC50
9.6 nM
 .
Modifier
 [1- 6]
 Target Info    Kv4.2 IC50
13.2 nM
 .
Modifier
 [1- 6]
 Target Info    Kv2.1 IC50
14.3 nM
 . . [1- 7]
 Target Info    tetrodotoxin (TTX)-sensitive sodium channel IC50
27.6 nM
 .
Root ganglion neurons
 [1- 7]
 Target Info    tetrodotoxin (TTX)-sensitive sodium channel IC50
30.2 nM
 .
Root ganglion neurons
 [1- 7]
 Target Info    Kv IC50
52.3 nM
 .
Modifier
 [1- 6]
 Target Info    Nav1.3 IC50
292 nM
 . . [1- 7]
 Target Info    Kv4.3 IC50
425.1 nM
 . . [1- 7]
 Target Info    Kv4.3 IC50
425.1 nM
 .
Modifier
 [1- 6]
 Target Info    Kv4.2 IC50
604.2 nM
 . . [1- 7]
 Target Info    Kv4.2 IC50
604.2 nM
 .
Modifier
 [1- 6]
 Target Info    tetrodotoxin (TTX)-sensitive sodium channel IC50
927 nM
 . . [1- 7]
 Target Info    tetrodotoxin (TTX)-sensitive sodium channel IC50
927 nM
 . . [1- 7]
 Target Info    Nav1.7 IC50
>1 μM
 . . [1- 7]
 Target Info    Nav1.5 IC50
2.3 - 2.9 μM
 . . [1- 7]
References
Ref 1 Isolation and characterization of Jingzhaotoxin-V, a novel neurotoxin from the venom of the spider Chilobrachys jingzhao. Toxicon. 2007 Mar 1;49(3):388-99. doi: 10.1016/j.toxicon.2006.10.012. Epub 2006 Nov 6.
Ref 2 Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao. Proteomics. 2007 Jun;7(11):1892-907. doi: 10.1002/pmic.200600785.
Ref 3 Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. doi: 10.1016/j.bbrc.2006.11.086. Epub 2006 Nov 27.
Ref 4 Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. doi: 10.1007/s00018-008-8135-x.
Ref 5 Molecular surface of JZTX-V (-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4. Toxins (Basel). 2014 Jul 23;6(7):2177-93. doi: 10.3390/toxins6072177.
Ref 6 Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V. PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018.
Ref 7 [Inhibition of Jingzhaotoxin-V on Kv4.3 channel]. Sheng Li Xue Bao. 2010 Jun 25;62(3):255-60.
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