Peptide Information

General Information of This Peptide
Peptide ID
BTDP004914
Peptide Name
Mu-scoloptoxin(03)-Ssm2a
Symonym
Mu-scoloptoxin-Ssm6a
Species
Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Uniprot Name
TX32A_SCOMU
Alphafold ID
P0DL36
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MUN
Sequence
MRIWSLTRILTFIVIFNFAEAGGECMKKCDSPDMIREIFTRCTMVKRDTQFSENSGHLIP
KRSVVADNKCENSLRREIACGQCRDKVKTDGYFYECCTSDSTFKKCQDLLHK
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Sequence Length
112
Mass (Da)
12990
Signal Sequence
MRIWSLTRILTFIVIFNFAEA
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Sequence Removed Signal Peptide
GGECMKKCDSPDMIREIFTRCTMVKRDTQFSENSGHLIPKRSVVADNKCENSLRREIACG
QCRDKVKTDGYFYECCTSDSTFKKCQDLLHK
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Disulfide Bond
70-97;80-96;83-106
PDB ID
2MUN , 2MZ4
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Chilopoda
Order: Scolopendromorpha
Family: Scolopendridae
Genus: Scolopendra
Species: Scolopendra mutilans
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Nav1.7 IC50
25.4 nM
 . . [1], [2], [3]
 Target Info    Nav1.2 IC50
813 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 IC50
4.1 μM
 . . [1], [2], [3]
 Target Info    Nav1.6 IC50
15.2 μM
 . . [1], [2], [3]
References
Ref 1 Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17534-9. doi: 10.1073/pnas.1306285110. Epub 2013 Sep 30.
Ref 2 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
Ref 3 Weaponization of a Hormone: Convergent Recruitment of Hyperglycemic Hormone into the Venom of Arthropod Predators. Structure. 2015 Jul 7;23(7):1283-92. doi: 10.1016/j.str.2015.05.003. Epub 2015 Jun 11.
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