Peptide Information

General Information of This Peptide
Peptide ID
BTDP008719
Peptide Name
M-theraphotoxin-Gr1a
Symonym
GsMTx-4; GsMTx-IV
Species
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Uniprot Name
MTX4_GRARO
Alphafold ID
Q7YT39
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1LU8
Sequence
MKTSVVFVIAGLALLSVVCYASELKEQSSVNEVLSTIFHFEQPEERGCLEFWWKCNPNDD
KCCRPKLKCSKLFKLCNFSFGK
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Sequence Length
82
Mass (Da)
9400
Sequence Removed Signal Peptide
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
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Disulfide Bond
48-63;55-69;62-76
PDB ID
1LU8 , 1TYK
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola rosea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KvAP Inhibition rate .
20 μM
Modifier
 [1- 14]
 Target Info    Kv1.1 Inhibition rate .
88 μM
Modifier
 [1- 14]
 Target Info    Kv1.4 Inhibition rate .
85 μM
Modifier
 [1- 14]
 Target Info    Nav1.1 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Nav1.2 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Nav1.3 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Nav1.4 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Nav1.5 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Nav1.6 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Nav1.7 IC50
7.4 - 14 μM
 .
Modifier
 [1- 14]
 Target Info    Kv11.2 IC50
10.9 μM
 .
Modifier
 [1- 14]
 Target Info    Kv11 IC50
11 μM
 .
Modifier
 [1- 14]
 Target Info    Kv11.1 IC50
11 μM
 .
Modifier
 [1- 14]
 Target Info    Kv11.2 IC50
11 μM
 .
Modifier
 [1- 14]
 Target Info    Kv11.3 IC50
53 μM
 .
Modifier
 [1- 14]
 Target Info    Kv1.1 IC50
53 - 85 μM
 .
Modifier
 [1- 14]
 Target Info    Kv1.4 IC50
53 - 85 μM
 .
Modifier
 [1- 14]
 Target Info    Kv11.3 IC50
53 - 85 μM
 .
Modifier
 [1- 14]
References
Ref 1 cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon. 2003 Sep;42(3):263-74. doi: 10.1016/s0041-0101(03)00141-7.
Ref 2 Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 2011 Sep 1;58(3):265-76. doi: 10.1016/j.toxicon.2011.06.006. Epub 2011 Jun 28.
Ref 3 Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583-98. doi: 10.1085/jgp.115.5.583.
Ref 4 Solution structure of peptide toxins that block mechanosensitive ion channels. J Biol Chem. 2002 Sep 13;277(37):34443-50. doi: 10.1074/jbc.M202715200. Epub 2002 Jun 24.
Ref 5 Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. doi: 10.1074/jbc.M109.054718. Epub 2009 Dec 2.
Ref 6 Tarantula peptide inhibits atrial fibrillation. Nature. 2001 Jan 4;409(6816):35-6. doi: 10.1038/35051165.
Ref 7 Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry. 2004 Aug 10;43(31):10071-9. doi: 10.1021/bi049463y.
Ref 8 Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004 Jul 8;430(6996):235-40. doi: 10.1038/nature02743.
Ref 9 Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-8. doi: 10.1016/j.bbrc.2005.12.046. Epub 2005 Dec 19.
Ref 10 Effects of tarantula toxin GsMTx4 on the membrane motor of outer hair cells. Neurosci Lett. 2006 Aug 14;404(1-2):213-6. doi: 10.1016/j.neulet.2006.05.059. Epub 2006 Jun 22.
Ref 11 Molecular dynamics simulations of a stretch-activated channel inhibitor GsMTx4 with lipid membranes: two binding modes and effects of lipid structure. Biophys J. 2007 Jun 15;92(12):4233-43. doi: 10.1529/biophysj.106.101071. Epub 2007 Mar 23.
Ref 12 Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers?. Biophys J. 2007 Aug 15;93(4):L20-2. doi: 10.1529/biophysj.107.112375. Epub 2007 Jun 15.
Ref 13 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 14 Fast desensitization of acetylcholine receptors induced by a spider toxin. Channels (Austin). 2021 Dec;15(1):507-515. doi: 10.1080/19336950.2021.1961459.
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