Peptide Information

General Information of This Peptide
Peptide ID
BTDP008640
Peptide Name
Mu-theraphotoxin-Pspp1
Symonym
Phlotoxin 1
Species
Phlogiellus sp. (Tarantula)
Uniprot Name
TXP1_PHLXX
Alphafold ID
P0DM14
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DM14
Sequence
ACLGQWDSCDPKASKCCPNYACEWKYPWCRYKLF
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Sequence Length
34
Mass (Da)
4065
Sequence Removed Signal Peptide
ACLGQWDSCDPKASKCCPNYACEWKYPWCRYKLF
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Disulfide Bond
2-17;9-22;16-29
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Phlogiellus
Species: Phlogiellus sp. PE-2016
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv4.3 Inhibition rate .
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    K2p3.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv7.3 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv7.2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.6 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv3.2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kir1.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kir2.3 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv11 Inhibition rate .
100 μM
Blocker
 [4]
 Target Info    Kv2.2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv4.2 Inhibition rate .
1 μM
Blocker
 [3]
 Target Info    Kv3.4 Inhibition rate
20 %
1 μM
Blocker
 [3]
 Target Info    Kv3.4 Inhibition rate
20 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.4 Inhibition rate
35 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.6 Inhibition rate
35 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.7 Inhibition rate
90 %
1 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.2 IC50
73.7 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.3 IC50
201.5 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.7 IC50
254.3 - 260 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.7 IC50
254.3 ± 147.6 nM
 . . [4]
 Target Info    Nav1.1 IC50
280.3 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.6 IC50
491.2 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.5 IC50
710.6 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv11.1 IC50
>10 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.8 IC50
>10 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Nav1.4 IC50
>2.1 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Cav1.2 IC50
5.9 μM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883.
Ref 2 Corrigendum: Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816.
Ref 3 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 4 Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates. Toxins (Basel). 2019 Aug 22;11(9):484. doi: 10.3390/toxins11090484.
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