Peptide Information

General Information of This Peptide
Peptide ID
BTDP005662
Peptide Name
Omega toxin Ap5
Species
Acanthoscurria paulensis (Brazilian giant black tarantula spider)
Uniprot Name
TX35_ACAPA
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
MNTIQVILFAVVLVLTVTVGQADEDSAETSLLRKLEEAEASMFGQYLEESKNSREKRCAV
ENVPCDKDRPGCCREYECLKPTGYGWWYGSYYCYKKKERLIST
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Sequence Length
103
Mass (Da)
11834
Signal Sequence
MNTIQVILFAVVLVLTVTVGQA
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Sequence Removed Signal Peptide
DEDSAETSLLRKLEEAEASMFGQYLEESKNSREKRCAVENVPCDKDRPGCCREYECLKPT
GYGWWYGSYYCYKKKERLIST
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Disulfide Bond
58-73;65-78;72-93
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Acanthoscurria
Species: Acanthoscurria paulensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.5 Inhibition rate
4.2 %
1 μM
 . [1]
 Target Info    Nav1.1 Inhibition rate
6.6 %
1 μM
 . [1]
 Target Info    Nav1.7 Inhibition rate
16 %
1 μM
 . [1]
 Target Info    Cav2.1 Inhibition rate
22.08 %
1 μM
 . [1]
 Target Info    Cav2.1 Inhibition rate
28.06 %
1 μM
 . [1]
References
Ref 1 Purification and characterization of peptides Ap2, Ap3 and Ap5 (-toxins) from the venom of the Brazilian tarantula Acanthoscurria paulensis. Peptides. 2021 Nov;145:170622. doi: 10.1016/j.peptides.2021.170622. Epub 2021 Aug 5.
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