Peptide Information

General Information of This Peptide
Peptide ID
BTDP005366
Peptide Name
Beta/mu-theraphotoxin-Pe1b
Symonym
Beta/mu-TRTX-Pe1b
Species
Phormingochilus everetti (Malaysian purple earth tiger tarantula)
Uniprot Name
PE1B_PHOEV
Alphafold ID
P0DQN2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQN2
Sequence
ECRYWLGGCSKTGDCCEHLSCSPKWHWCVWDGTF
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Sequence Length
34
Mass (Da)
3982
Sequence Removed Signal Peptide
ECRYWLGGCSKTGDCCEHLSCSPKWHWCVWDGTF
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Disulfide Bond
2-16;9-21;15-28
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Phormingochilus
Species: Phormingochilus everetti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
167 nM
 . . [1]
 Target Info    Nav1.6 IC50
696 nM
 . . [1]
 Target Info    Nav1.5 IC50
>10 μM
 . . [1]
 Target Info    Nav1.2 IC50
3.54 μM
 . . [1]
References
Ref 1 Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na(V)1.7. Biochem Pharmacol. 2020 Nov;181:114080. doi: 10.1016/j.bcp.2020.114080. Epub 2020 Jun 6.
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