Peptide Information

General Information of This Peptide
Peptide ID
BTDP005367
Peptide Name
Beta/omega-theraphotoxin-Bp1a
Symonym
Protoxin-I analog
Species
Bumba pulcherrimaklaasi (Tarantula spider) (Euathlus pulcherrimaklaasi)
Uniprot Name
TXPR1_BUMPU
Alphafold ID
P0DQN3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DQN3
Sequence
ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS
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Sequence Length
35
Mass (Da)
3994
Sequence Removed Signal Peptide
ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS
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Disulfide Bond
2-16;9-21;15-28
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Bumba
Species: Bumba pulcherrimaklaasi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.6 IC50
21 - 133 nM
 . . [1]
 Target Info    Nav1.7 IC50
51 - 95 nM
 . . [1]
 Target Info    Cav3.1 IC50
53 nM
 . . [1]
 Target Info    Nav1.2 IC50
60 - 104 nM
 . . [1]
 Target Info    Nav1.5 IC50
76 - 358 nM
 . . [1]
 Target Info    TRPA1 IC50
389 nM
 . . [1]
 Target Info    Kv2.1 IC50
411 nM
 . . [1]
References
Ref 1 Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na(V)1.7. Biochem Pharmacol. 2020 Nov;181:114080. doi: 10.1016/j.bcp.2020.114080. Epub 2020 Jun 6.
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