Peptide Information

General Information of This Peptide
Peptide ID
BTDP008396
Peptide Name
Kappa-theraphotoxin-Gr2c
Symonym
GTx2-1-1; GsAF II; GsAf2; Mechanotoxin-alpha
Species
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Uniprot Name
AF2_GRARO
Alphafold ID
P61409
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P61409
Sequence
MKAFFVILGLALLCAYSFALEEQDQLSLRNDLLTVMFAENSELTPETEERYCQKWMWTCD
EERKCCEGLVCRLWCKKKIEW
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Sequence Length
81
Mass (Da)
9679
Signal Sequence
MKAFFVILGLALLCAYSFA
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Sequence Removed Signal Peptide
LEEQDQLSLRNDLLTVMFAENSELTPETEERYCQKWMWTCDEERKCCEGLVCRLWCKKKI
EW
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Disulfide Bond
52-66;59-71;65-75
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola rosea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
2 mM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.4 Inhibition rate .
2 mM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv11.2 Inhibition rate .
2 mM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv11.3 Inhibition rate .
2 mM
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.1 IC50
>200 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv1.4 IC50
>200 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv11.2 IC50
>200 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv11.3 IC50
>200 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.5 IC50
>40 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.7 IC50
0.0136 - 1.03 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.4 IC50
4 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv11 IC50
4.7 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Kv11.1 IC50
4.7 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.1 IC50
5.7 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.6 IC50
6.6 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.2 IC50
12 μM
 .
Modifier
 [1], [2], [3], [4]
 Target Info    Nav1.3 IC50
24 μM
 .
Modifier
 [1], [2], [3], [4]
References
Ref 1 Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 2011 Sep 1;58(3):265-76. doi: 10.1016/j.toxicon.2011.06.006. Epub 2011 Jun 28.
Ref 2 Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. doi: 10.1074/jbc.M109.054718. Epub 2009 Dec 2.
Ref 3 Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17.
Ref 4 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
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