Peptide Information

General Information of This Peptide
Peptide ID
BTDP005376
Peptide Name
Mu/omega-theraphotoxin-Tap2a
Symonym
Mu/omega-TRTX-Tap2a
Species
Theraphosa apophysis (Goliath pinkfoot tarantula) (Pseudotheraphosa apophysis)
Uniprot Name
TAP2A_THEAO
Alphafold ID
P0DQO4
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQO4
Sequence
DCLGFMKPCDINNDKCCSSYVCGRNNHWCKFHL
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Sequence Length
33
Mass (Da)
3852
Sequence Removed Signal Peptide
DCLGFMKPCDINNDKCCSSYVCGRNNHWCKFHL
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Disulfide Bond
2-17;9-22;16-29
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Theraphosa
Species: Theraphosa apophysis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.1 IC50
169 - 621 nM
 . . [1]
 Target Info    Nav1.2 IC50
169 - 621 nM
 . . [1]
 Target Info    Nav1.6 IC50
169 - 621 nM
 . . [1]
 Target Info    Nav1.7 IC50
169 - 621 nM
 . . [1]
 Target Info    Cav3.1 IC50
169 - 621 nM
 . . [1]
 Target Info    Nav1.3 IC50
1.216 μM
 . . [1]
References
Ref 1 A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain. 2021 Feb 1;162(2):569-581. doi: 10.1097/j.pain.0000000000002041.
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