Peptide Information

General Information of This Peptide
Peptide ID
BTDP001535
Peptide Name
Mu-sparatoxin-Hv2
Symonym
U15-sparatoxin-Hv1a
Species
Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Uniprot Name
TXHV2_HETVE
Alphafold ID
A0A088BP94
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: A0A088BP94
Sequence
MKFAIVITLLLVAFSAVALADKSIERAVMDLITARDDDCGKLFADCTSDSDCCENWVCSK
TGFVKNICKYNFG
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Sequence Length
73
Mass (Da)
8006
Signal Sequence
MKFAIVITLLLVAFSAVALA
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Sequence Removed Signal Peptide
DKSIERAVMDLITARDDDCGKLFADCTSDSDCCENWVCSKTGFVKNICKYNFG
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Disulfide Bond
39-53;46-58;52-68
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Sparassidae
Genus: Heteropoda
Species: Heteropoda venatoria
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 Inhibition rate .
15 μM
Dorsal unpaired median (DUM) neurons
 [1]
 Target Info    Nav1.5 Inhibition rate .
15 μM
Dorsal unpaired median (DUM) neurons
 [1]
 Target Info    Nav1.7 Inhibition rate .
15 μM
Dorsal unpaired median (DUM) neurons
 [1]
 Target Info    Nav1.3 Inhibition rate
<10 %
15 μM
Dorsal unpaired median (DUM) neurons
 [1]
 Target Info    Nav1.4 Inhibition rate
<10 %
15 μM
Dorsal unpaired median (DUM) neurons
 [1]
 Target Info    KvAP Inhibition rate
15.4 %
10 μM
Dorsal unpaired median (DUM) neurons
 [1]
 Target Info    Nav IC50
833.7 nM
 .
Dorsal unpaired median (DUM) neurons
 [1]
References
Ref 1 Purification and Characterization of a Novel Insecticidal Toxin, -sparatoxin-Hv2, from the Venom of the Spider Heteropoda venatoria. Toxins (Basel). 2018 Jun 7;10(6):233. doi: 10.3390/toxins10060233.
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