Peptide Information

General Information of This Peptide
Peptide ID
BTDP004024
Peptide Name
Mu-conotoxin KIIIB
Species
Conus kinoshitai (Kinoshita's cone)
Uniprot Name
CM3A_CONKI
Alphafold ID
P0C195
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2LXG
Sequence
KRNGCCNCSSKWCRDHSRCCGR
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Sequence Length
22
Mass (Da)
2560
Sequence Removed Signal Peptide
KRNGCCNCSSKWCRDHSRCCGR
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Disulfide Bond
5-20;5-19;5-13;6-19;6-13;8-20;8-19
PDB ID
2LXG , 6J8E , 7SAV , 7SAW
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus kinoshitai
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 Dissociation constant
230 nM
 .
Mu-conotoxin KIIIA-P2
 [1- 13]
 Target Info    Nav1.2 Dissociation constant
470 nM
 .
Mu-conotoxin KIIIB-P1
 [1- 13]
 Target Info    Nav1.4 Dissociation constant
830 nM
 .
Mu-conotoxin KIIIA-P4
 [1- 13]
 Target Info    Nav1.7 Dissociation constant
1.57 μM
 .
Mu-conotoxin KIIIA-P6
 [1- 13]
 Target Info    Nav1.2 IC50
5 - 124 nM
 .
Mu-conotoxin KIIIA-P1
 [1- 13]
 Target Info    Nav1.4 IC50
20 - 90 nM
 .
Mu-conotoxin KIIIA-P2
 [1- 13]
 Target Info    Nav1.2 IC50
26 nM
 .
Mu-conotoxin KIIIB-P2
 [1- 13]
 Target Info    Nav1.4 IC50
472 nM
 .
Mu-conotoxin KIIIA-N
 [1- 13]
 Target Info    Nav1.2 IC50
875 nM
 .
Mu-conotoxin KIIIA-N
 [1- 13]
 Target Info    Nav1.7 IC50
887 nM
 .
Mu-conotoxin KIIIA-N
 [1- 13]
 Target Info    Nav1.2 IC50
1.37 μM
 .
Mu-conotoxin KIIIA-P3
 [1- 13]
 Target Info    Nav1.4 IC50
2 μM
 .
Mu-conotoxin KIIIA-P5
 [1- 13]
 Target Info    Nav1.7 IC50
5.4 μM
 .
Mu-conotoxin KIIIA-P7
 [1- 13]
References
Ref 1 Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry. 2005 May 17;44(19):7259-65. doi: 10.1021/bi0473408.
Ref 2 Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. doi: 10.1074/jbc.M704616200. Epub 2007 Aug 27.
Ref 3 Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan;53(1):90-8. doi: 10.1016/j.toxicon.2008.10.017. Epub 2008 Nov 20.
Ref 4 Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin). 2009 Jan-Feb;3(1):32-8. doi: 10.4161/chan.3.1.7500. Epub 2009 Jan 25.
Ref 5 Importance of position 8 in -conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. 2011 Sep;278(18):3408-18. doi: 10.1111/j.1742-4658.2011.08264.x. Epub 2011 Aug 24.
Ref 6 Interactions of key charged residues contributing to selective block of neuronal sodium channels by -conotoxin KIIIA. Mol Pharmacol. 2011 Oct;80(4):573-84. doi: 10.1124/mol.111.073460. Epub 2011 Jun 27.
Ref 7 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7.
Ref 8 Co-expression of Na(V) subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking -conotoxins. Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051.
Ref 9 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
Ref 10 Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 2009 Feb 17;48(6):1210-9. doi: 10.1021/bi801998a.
Ref 11 Distinct disulfide isomers of -conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry. 2012 Dec 11;51(49):9826-35. doi: 10.1021/bi301256s. Epub 2012 Nov 28.
Ref 12 Molecular basis for pore blockade of human Na(+) channel Na(v)1.2 by the -conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313. doi: 10.1126/science.aaw2999. Epub 2019 Feb 14.
Ref 13 Structural and functional insights into the inhibition of human voltage-gated sodium channels by -conotoxin KIIIA disulfide isomers. J Biol Chem. 2022 Mar;298(3):101728. doi: 10.1016/j.jbc.2022.101728. Epub 2022 Feb 12.
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