Peptide Information

General Information of This Peptide
Peptide ID
BTDP008117
Peptide Name
Beta-toxin Cn8
Symonym
Toxin II-13.4
Species
Centruroides noxius (Mexican scorpion)
Uniprot Name
SCX8_CENNO
Alphafold ID
Q9TWL0
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q9TWL0
Sequence
KEGYIVNYYTGCKFACAKLGDNDYCLRECKARYGKGAGGYCYAFGCWCTHLYEQAVVWPL
PKKKCRA
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Sequence Length
67
Mass (Da)
7634
Sequence Removed Signal Peptide
KEGYIVNYYTGCKFACAKLGDNDYCLRECKARYGKGAGGYCYAFGCWCTHLYEQAVVWPL
PKKKCRA
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Disulfide Bond
12-65;16-41;25-46;29-48
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides noxius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Inhibition rate .
140 nM
 . [1], [2]
 Target Info    Nav1.6 IC50
67.7 nM
 . . [1], [2]
References
Ref 1 Negative-shift activation, current reduction and resurgent currents induced by -toxins from Centruroides scorpions in sodium channels. Toxicon. 2012 Feb;59(2):283-93. doi: 10.1016/j.toxicon.2011.12.003. Epub 2011 Dec 16.
Ref 2 Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann. J Biochem. 1994 Dec;116(6):1383-91. doi: 10.1093/oxfordjournals.jbchem.a124691.
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