Peptide Information

General Information of This Peptide
Peptide ID
BTDP007196
Peptide Name
Sodium channel inhibitor ISTX-I
Species
Ixodes scapularis (Black-legged tick) (Deer tick)
Uniprot Name
ISTX_IXOSC
Alphafold ID
Q4PN35
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2NDI
Sequence
MNKFTVALVSTLLLGMLRITVSAQPLENEAVSADEPSAGGKLCSENGDCAADECCVDTVF
EGDMVTRSCEKTTGNFTECPGLTPIAKK
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Sequence Length
88
Mass (Da)
9233
Signal Sequence
MNKFTVALVSTLLLGMLRITVSA
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Sequence Removed Signal Peptide
QPLENEAVSADEPSAGGKLCSENGDCAADECCVDTVFEGDMVTRSCEKTTGNFTECPGLT
PIAKK
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Disulfide Bond
43-55;49-69;54-79
PDB ID
2NDI
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Ixodida
Family: Ixodidae
Genus: Ixodes
Species: Ixodes scapularis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
1.6 μM
 . . [1], [2]
References
Ref 1 An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochem Mol Biol. 2006 Feb;36(2):111-29. doi: 10.1016/j.ibmb.2005.11.005. Epub 2005 Dec 20.
Ref 2 A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds. Sci Rep. 2016 Jul 13;6:29691. doi: 10.1038/srep29691.
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