Peptide Information

General Information of This Peptide
Peptide ID
BTDP003258
Peptide Name
Hainantoxin-III 12
Symonym
Hainantoxin-3.12; Mu-theraphotoxin-Hhn2a; Peptide F7-18.76
Species
Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Uniprot Name
H3A12_CYRHA
Alphafold ID
D2Y2I3
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: D2Y2I3
Sequence
MKASMFLALAGLVLLFVVGYASGSEEKEFPRELLSKIFAVDDFKGEERGCKGFGDSCTPG
KNECCPNYACSSKHKWCKVYLGK
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Sequence Length
83
Mass (Da)
9123
Signal Sequence
MKASMFLALAGLVLLFVVGYASG
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Sequence Removed Signal Peptide
SEEKEFPRELLSKIFAVDDFKGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
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Disulfide Bond
50-65;57-70;64-77
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Haplopelma
Species: Haplopelma hainanum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
232 nM
 . . [1], [2], [3]
 Target Info    Nav1.2 IC50
270 nM
 . . [1], [2], [3]
 Target Info    Nav1.3 IC50
491 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 IC50
1.27 μM
 . . [1], [2], [3]
References
Ref 1 Molecular diversification of peptide toxins from the tarantula Haplopelma hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses. J Proteome Res. 2010 May 7;9(5):2550-64. doi: 10.1021/pr1000016.
Ref 2 Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol. 2003 Sep 5;477(1):1-7. doi: 10.1016/s0014-2999(03)02190-3.
Ref 3 Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana. J Biol Chem. 2013 Jul 12;288(28):20392-403. doi: 10.1074/jbc.M112.426627. Epub 2013 May 23.
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