Peptide Information

General Information of This Peptide
Peptide ID
BTDP006616
Peptide Name
Beta-theraphotoxin-Cm1a
Symonym
CcoTx-I; Ceratotoxin-1
Species
Ceratogyrus marshalli (Straighthorned baboon tarantula) (Ceratogyrus cornuatus)
Uniprot Name
TX1_CERMR
Alphafold ID
P84507
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5EPM
Sequence
DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYDL
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Sequence Length
33
Mass (Da)
4052
Sequence Removed Signal Peptide
DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYDL
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Disulfide Bond
2-17;9-22;16-29
PDB ID
5EPM , 6BR0
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Ceratogyrus
Species: Ceratogyrus marshalli
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
2.7 nM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.7 IC50
2.8 nM
 .
Synthetic variant D1Z/M5I/R27Na
 [1], [2], [3], [4]
 Target Info    Nav1.2 IC50
3 - 70 nM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.7 IC50
129.1 - 5120 nM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.5 IC50
188 - 323 nM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.4 IC50
263 - 888 nM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Cav2.2 IC50
400 nM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.4 IC50
>3 μM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.4 IC50
>3 μM
 .
Synthetic variant D1Z/M5I/R27Na
 [1], [2], [3], [4]
 Target Info    Nav1.5 IC50
>3 μM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
 Target Info    Nav1.5 IC50
>3 μM
 .
Synthetic variant D1Z/M5I/R27Na
 [1], [2], [3], [4]
 Target Info    Nav1.1 IC50
0.523 - 1.06 μM
 .
Synthetic variant D1Z/M5I/K18Y/R24Ka
 [1], [2], [3], [4]
References
Ref 1 Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29. doi: 10.1124/mol.105.015941. Epub 2005 Nov 2.
Ref 2 Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J Biol Chem. 2016 Jul 1;291(27):13974-13986. doi: 10.1074/jbc.M116.725978. Epub 2016 Apr 22.
Ref 3 Discovery and mode of action of a novel analgesic -toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.
Ref 4 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
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