Peptide Information

General Information of This Peptide
Peptide ID
BTDP008342
Peptide Name
Mu-conotoxin GVIIJ
Symonym
Conotoxin muO-GVIIJ; MuO'section sign'-GVIIJ
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
O17J_CONGE
Alphafold ID
X5IWS1
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2N8H
Sequence
MKLTCVVIVAALLLTACQLITALDCGGTQKHRALRSTIKLSLLRQHRGWCGDPGATCGKL
RLYCCSGFCDCYTKTCKDKSSA
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Sequence Length
82
Mass (Da)
8871
Signal Sequence
MKLTCVVIVAALLLTACQLITA
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Sequence Removed Signal Peptide
LDCGGTQKHRALRSTIKLSLLRQHRGWCGDPGATCGKLRLYCCSGFCDCYTKTCKDKSSA
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Disulfide Bond
50-65;57-69;64-76
PDB ID
2N8H
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Dissociation constant
4.7 nM
 . . [1- 5]
 Target Info    Nav1.1 Dissociation constant
11 nM
 . . [1- 5]
 Target Info    Nav1.2 Dissociation constant
11 nM
 . . [1- 5]
 Target Info    Nav1.3 Dissociation constant
15 nM
 . . [1- 5]
 Target Info    Nav1.7 Dissociation constant
41 nM
 . . [1- 5]
 Target Info    Nav1.6 Dissociation constant
360 nM
 . . [1- 5]
 Target Info    Nav1.5 Dissociation constant
207 μM
 . . [1- 5]
 Target Info    Nav1.8 Inhibition rate . . . [1- 5]
References
Ref 1 Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nat Commun. 2014 Mar 24;5:3521. doi: 10.1038/ncomms4521.
Ref 2 A disulfide tether stabilizes the block of sodium channels by the conotoxin O-GVIIJ. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2758-63. doi: 10.1073/pnas.1324189111. Epub 2014 Feb 4.
Ref 3 Probing the Redox States of Sodium Channel Cysteines at the Binding Site of O-Conotoxin GVIIJ. Biochemistry. 2015 Jun 30;54(25):3911-20. doi: 10.1021/acs.biochem.5b00390. Epub 2015 Jun 18.
Ref 4 - and -subunit composition of voltage-gated sodium channels investigated with -conotoxins and the recently discovered O-conotoxin GVIIJ. J Neurophysiol. 2015 Apr 1;113(7):2289-301. doi: 10.1152/jn.01004.2014. Epub 2015 Jan 28.
Ref 5 Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin O-GVIIJ. J Biol Chem. 2016 Mar 25;291(13):7205-20. doi: 10.1074/jbc.M115.697672. Epub 2016 Jan 27.
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