Peptide Information

General Information of This Peptide
Peptide ID
BTDP003370
Peptide Name
Omega-theraphotoxin-Pm1a
Symonym
Omega-theraphotoxin-Cc1a; Toxin-like GVDKE
Species
Pelinobius muticus (King baboon spider) (Citharischius crawshayi)
Uniprot Name
TXO1A_PELMU
Alphafold ID
D5J6X1
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: D5J6X1
Sequence
MKTSMLAVFVALPLAFVLTAATEERAHPNELVNSLVELVKLDAERGVDKEGCKYMFGSCG
KSDDCCPKLACKRTFNYCAWDGSV
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Sequence Length
84
Mass (Da)
9195
Signal Sequence
MKTSMLAVFVALPLAFVLTAA
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Sequence Removed Signal Peptide
TEERAHPNELVNSLVELVKLDAERGVDKEGCKYMFGSCGKSDDCCPKLACKRTFNYCAWD
GSV
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Disulfide Bond
52-66;59-71;65-78
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Pelinobius
Species: Pelinobius muticus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav2.1 Inhibition rate . . . [1], [2]
 Target Info    Cav2.3 Inhibition rate . . . [1], [2]
 Target Info    Nav1.7 Inhibition rate
17 %
3 μM
 . [1], [2]
 Target Info    Cav2.2 Inhibition rate
20 %
3 μM
 . [1], [2]
 Target Info    Nav1.5 Inhibition rate
39 %
3 μM
 . [1], [2]
 Target Info    Cav1.2 IC50
825 nM
 . . [1], [2]
 Target Info    Cav1.3 IC50
2.24 μM
 . . [1], [2]
References
Ref 1 Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function. Cell Mol Life Sci. 2010 Aug;67(16):2799-813. doi: 10.1007/s00018-010-0359-x. Epub 2010 Apr 6.
Ref 2 Isolation, synthesis and characterization of -TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19.
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