Peptide Information

General Information of This Peptide
Peptide ID
BTDP008572
Peptide Name
Kappa-theraphotoxin-Aa1a
Species
Avicularia aurantiaca (Yellow-banded pinktoe tarantula)
Uniprot Name
NTA_AVIAU
Alphafold ID
A0A3F2YLP5
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5WLX
Sequence
GDCHKFLGWCRGEKDPCCEHLTCHVKHGWCVWDGTI
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Sequence Length
36
Mass (Da)
4158
Sequence Removed Signal Peptide
GDCHKFLGWCRGEKDPCCEHLTCHVKHGWCVWDGTI
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Disulfide Bond
3-18;10-23;17-30
PDB ID
5WLX
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Avicularia
Species: Avicularia aurantiaca
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv11.1 IC50
637 nM
 .
Blocker
 [1]
 Target Info    Kv10 IC50
637 nM
 .
Blocker
 [1]
 Target Info    Nav1.2 IC50
1.449 μM
 .
Blocker
 [1]
 Target Info    Nav1.7 IC50
1.528 μM
 .
Blocker
 [1]
 Target Info    Nav1.5 IC50
7.316 μM
 .
Blocker
 [1]
 Target Info    Kv11 IC50
8.511 μM
 .
Blocker
 [1]
 Target Info    Kv11.1 IC50
8.511 μM
 .
Blocker
 [1]
References
Ref 1 Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25.
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