Peptide Information

General Information of This Peptide
Peptide ID
BTDP008693
Peptide Name
Beta/omega-theraphotoxin-Tp1a
Symonym
Protoxin-1; Protoxin-I
Species
Thrixopelma pruriens (Peruvian green velvet tarantula)
Uniprot Name
TXPR1_THRPR
Alphafold ID
P83480
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2M9L
Sequence
ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS
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Sequence Length
35
Mass (Da)
3994
Sequence Removed Signal Peptide
ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS
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Disulfide Bond
2-16;9-21;15-28
PDB ID
2M9L
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Thrixopelma
Species: Thrixopelma pruriens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
6 %
730 nM
Modifier
 [1- 9]
 Target Info    Kv1.5 Inhibition rate
7 %
730 nM
Modifier
 [1- 9]
 Target Info    Kv1.3 Inhibition rate
40 %
730 nM
Modifier
 [1- 9]
 Target Info    Kv2.1 Inhibition rate
60 %
730 nM
Modifier
 [1- 9]
 Target Info    Nav1.6 IC50
21 - 133 nM
 .
Modifier
 [1- 9]
 Target Info    Nav1.7 IC50
51 - 95 nM
 .
Modifier
 [1- 9]
 Target Info    Cav3.1 IC50
53 nM
 .
Modifier
 [1- 9]
 Target Info    Nav1.2 IC50
60 - 104 nM
 .
Modifier
 [1- 9]
 Target Info    Nav1.5 IC50
76 - 358 nM
 .
Modifier
 [1- 9]
 Target Info    TRPA1 IC50
389 nM
 .
Modifier
 [1- 9]
 Target Info    Kv2.1 IC50
411 nM
 .
Modifier
 [1- 9]
 Target Info    Kv2.1 IC50
411 nM
 .
Modifier
 [1- 9]
References
Ref 1 Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry. 2002 Dec 17;41(50):14734-47. doi: 10.1021/bi026546a.
Ref 2 ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels. Toxicon. 2007 Feb;49(2):194-201. doi: 10.1016/j.toxicon.2006.09.014. Epub 2006 Sep 27.
Ref 3 Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ Channels Cav3.1 and Cav3.2. J Pharmacol Sci. 2010;112(4):452-8. doi: 10.1254/jphs.09356fp. Epub 2010 Mar 30.
Ref 4 Block of T-type calcium channels by protoxins I and II. Mol Brain. 2014 May 9;7:36. doi: 10.1186/1756-6606-7-36.
Ref 5 High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots. Int J Pept. 2015;2015:537508. doi: 10.1155/2015/537508. Epub 2015 Dec 30.
Ref 6 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 7 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 8 Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na(V)1.7. Biochem Pharmacol. 2020 Nov;181:114080. doi: 10.1016/j.bcp.2020.114080. Epub 2020 Jun 6.
Ref 9 A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.
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