Peptide Information

General Information of This Peptide
Peptide ID
BTDP006617
Peptide Name
Beta-theraphotoxin-Cm1b
Symonym
CcoTx-II; Ceratotoxin-2
Species
Ceratogyrus marshalli (Straighthorned baboon tarantula) (Ceratogyrus cornuatus)
Uniprot Name
TX2_CERMR
Alphafold ID
P84508
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6BTV
Sequence
DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYYL
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Sequence Length
33
Mass (Da)
4100
Sequence Removed Signal Peptide
DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYYL
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Disulfide Bond
2-17;9-22;16-29
PDB ID
6BTV
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Ceratogyrus
Species: Ceratogyrus marshalli
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 IC50
3.7 - 80 nM
 . . [1], [2], [3]
 Target Info    Nav1.7 IC50
95.5 - 230 nM
 . . [1], [2], [3]
 Target Info    Nav1.4 IC50
113 - 400 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 IC50
170 - 407 nM
 . . [1], [2], [3]
 Target Info    Nav1.6 IC50
0.0499 - 3.990 μM
 . . [1], [2], [3]
 Target Info    Nav1.3 IC50
0.088 - 5.570 μM
 . . [1], [2], [3]
 Target Info    Cav2.2 IC50
1.1 μM
 . . [1], [2], [3]
 Target Info    Nav1.5 IC50
1.524 - 1.634 μM
 . . [1], [2], [3]
References
Ref 1 Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29. doi: 10.1124/mol.105.015941. Epub 2005 Nov 2.
Ref 2 Discovery and mode of action of a novel analgesic -toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.
Ref 3 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
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