Peptide Information

General Information of This Peptide
Peptide ID
BTDP008397
Peptide Name
Kappa-theraphotoxin-Ps1a
Symonym
PaTx1; Phrixotoxin-1
Species
Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Uniprot Name
TXP1_PARSR
Alphafold ID
P61230
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1V7F
Sequence
YCQKWMWTCDSARKCCEGLVCRLWCKKII
   Click to Show/Hide
Sequence Length
29
Mass (Da)
3555
Sequence Removed Signal Peptide
YCQKWMWTCDSARKCCEGLVCRLWCKKII
   Click to Show/Hide
Disulfide Bond
2-16;9-21;15-25
PDB ID
1V7F
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Paraphysa
Species: Paraphysa scrofa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kir2.1 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    K2p2.1 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Kv1.1 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.2 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.3 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.4 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv1.5 Inhibition rate .
5 μM
 . [1], [2], [3]
 Target Info    Kv3.1 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Kv3.2 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Kv3.4 Inhibition rate .
1 μM
 . [1], [2], [3]
 Target Info    Kv11.1 Inhibition rate .
300 nM
 . [1], [2], [3]
 Target Info    Kv7.1 Inhibition rate .
300 nM
 . [1], [2], [3]
 Target Info    Kv2.1 Inhibition rate
6 %
500 nM
 . [1], [2], [3]
 Target Info    Kv2.2 Inhibition rate
16 %
500 nM
 . [1], [2], [3]
 Target Info    Kv4.1 Inhibition rate
39 %
250 nM
 . [1], [2], [3]
 Target Info    Kv4.2 IC50
5 nM
 . . [1], [2], [3]
 Target Info    Kv4.2 IC50
5 nM
 . . [1], [2], [3]
 Target Info    Kv4.3 IC50
28 nM
 . . [1], [2], [3]
 Target Info    Kv4.3 IC50
28 nM
 . . [1], [2], [3]
 Target Info    Nav1.7 IC50
423 nM
 . . [1], [2], [3]
References
Ref 1 Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol. 1999 Jan;126(1):251-63. doi: 10.1038/sj.bjp.0702283.
Ref 2 Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. J Med Chem. 2014 Aug 14;57(15):6623-31. doi: 10.1021/jm500687u. Epub 2014 Jul 24.
Ref 3 Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004 May;13(5):1197-208. doi: 10.1110/ps.03584304.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.