Peptide Information

General Information of This Peptide
Peptide ID
BTDP006164
Peptide Name
Beta-toxin Cll2
Symonym
Cll 2; Cll2
Species
Centruroides limpidus (Mexican scorpion)
Uniprot Name
SCX2_CENLI
Alphafold ID
P59898
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P59898
Sequence
KEGYLVNHSTGCKYECFKLGDNDYCLRECKQQYGKGAGGYCYAFGCWCNHLYEQAVVWPL
PKKTCN
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Sequence Length
66
Mass (Da)
7584
Sequence Removed Signal Peptide
KEGYLVNHSTGCKYECFKLGDNDYCLRECKQQYGKGAGGYCYAFGCWCNHLYEQAVVWPL
PKKTCN
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Disulfide Bond
12-65;16-41;25-46;29-48
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides limpidus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 Inhibition rate .
460 nM
 . [1], [2], [3]
 Target Info    Nav1.3 Inhibition rate .
460 nM
 . [1], [2], [3]
 Target Info    Nav1.7 Inhibition rate .
460 nM
 . [1], [2], [3]
 Target Info    Nav1.6 IC50
172 nM
 . . [1], [2], [3]
References
Ref 1 Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius. Comp Biochem Physiol B Biochem Mol Biol. 1996 Feb;113(2):331-9. doi: 10.1016/0305-0491(95)02031-4.
Ref 2 Negative-shift activation, current reduction and resurgent currents induced by -toxins from Centruroides scorpions in sodium channels. Toxicon. 2012 Feb;59(2):283-93. doi: 10.1016/j.toxicon.2011.12.003. Epub 2011 Dec 16.
Ref 3 Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms. Toxins (Basel). 2019 Jan 10;11(1):32. doi: 10.3390/toxins11010032.
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