Peptide Information

General Information of This Peptide
Peptide ID
BTDP004723
Peptide Name
Toxin GTx1-15
Symonym
Beta/omega-theraphotoxin-Gr2a; GpTx-1; GpTx-I
Species
Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Uniprot Name
TX15_GRARO
Alphafold ID
P0DJA9
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0DJA9
Sequence
MKTSVVFVIAGLALLSVACYASELKEQSSINEVLSTIFHFEQPEERDCLGFMRKCIPDND
KCCRPNLVCSRTHKWCKYVFGK
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Sequence Length
82
Mass (Da)
9364
Signal Sequence
MKTSVVFVIAGLALLSVACYA
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Sequence Removed Signal Peptide
SELKEQSSINEVLSTIFHFEQPEERDCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVFG
K
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Disulfide Bond
48-63;55-69;62-76
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Grammostola
Species: Grammostola rosea
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav3.1 Inhibition rate
30 %
9.8 nM
 . [1], [2]
 Target Info    Nav1.7 IC50
0.58 - 10 nM
 . . [1], [2]
 Target Info    Nav1.2 IC50
5 - 128 nM
 . . [1], [2]
 Target Info    Nav1.1 IC50
6 nM
 . . [1], [2]
 Target Info    Nav1.6 IC50
17 - 20.1 nM
 . . [1], [2]
 Target Info    Nav1.3 IC50
20.3 - 170 nM
 . . [1], [2]
 Target Info    Nav1.8 IC50
0.068 - 12.2 μM
 . . [1], [2]
 Target Info    Nav1.5 IC50
0.14 - >10 μM
 . . [1], [2]
 Target Info    Nav1.4 IC50
0.2 - >10 μM
 . . [1], [2]
References
Ref 1 Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon. 2011 Sep 1;58(3):265-76. doi: 10.1016/j.toxicon.2011.06.006. Epub 2011 Jun 28.
Ref 2 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
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