Peptide Information

General Information of This Peptide
Peptide ID
BTDP004954
Peptide Name
Mu-theraphotoxin-Pn3a
Symonym
Mu-TRTX-Pn3a
Species
Pamphobeteus nigricolor (Giant blue bloom tarantula)
Uniprot Name
PN3A_PAMNI
Alphafold ID
P0DM12
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5T4R
Sequence
DCRYMFGDCEKDEDCCKHLGCKRKMKYCAWDFTFT
   Click to Show/Hide
Sequence Length
35
Mass (Da)
4278
Sequence Removed Signal Peptide
DCRYMFGDCEKDEDCCKHLGCKRKMKYCAWDFTFT
   Click to Show/Hide
Disulfide Bond
2-16;9-21;15-28
PDB ID
5T4R
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Pamphobeteus
Species: Pamphobeteus nigricolor
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3 Inhibition rate .
10 μM
 . [1- 6]
 Target Info    nAChR alpha-7 Inhibition rate .
10 μM
 . [1- 6]
 Target Info    Kv2.1 Inhibition rate .
300 nM
 . [1- 6]
 Target Info    DRG neuron Inhibition rate
55 %
10 μM
 . [1- 6]
 Target Info    Cav2.1 Inhibition rate
60 - 80 %
10 μM
 . [1- 6]
 Target Info    Cav1.3 Inhibition rate
60 - 80 %
10 μM
 . [1- 6]
 Target Info    Cav2.2 Inhibition rate
60 - 80 %
10 μM
 . [1- 6]
 Target Info    Cav1.2 Inhibition rate
60 - 80 %
10 μM
 . [1- 6]
 Target Info    Nav1.7 IC50
0.9 - 4.4 nM
 . . [1- 6]
 Target Info    Nav1.1 IC50
37 nM
 . . [1- 6]
 Target Info    Nav1.2 IC50
124 nM
 . . [1- 6]
 Target Info    Nav1.6 IC50
129 nM
 . . [1- 6]
 Target Info    Nav1.4 IC50
144 nM
 . . [1- 6]
 Target Info    Nav1.3 IC50
210 nM
 . . [1- 6]
 Target Info    Nav1.5 IC50
800 nM
 . . [1- 6]
 Target Info    Cav3.3 IC50
960 nM
 . . [1- 6]
 Target Info    Nav1.7 IC50
1.457 μM
 . . [1- 6]
 Target Info    Nav1.9 IC50
2.427 μM
 . . [1- 6]
 Target Info    Cav2.2 IC50
3.71 μM
 . . [1- 6]
 Target Info    Nav1.8 IC50
50 μM
 . . [1- 6]
References
Ref 1 Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883.
Ref 2 Corrigendum: Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a. Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816.
Ref 3 Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain. 2019 Aug;160(8):1766-1780. doi: 10.1097/j.pain.0000000000001567.
Ref 4 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 5 Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels. Front Pharmacol. 2021 Jan 28;11:633679. doi: 10.3389/fphar.2020.633679. eCollection 2020.
Ref 6 -Theraphotoxin Pn3a inhibition of Ca(V)3.3 channels reveals a novel isoform-selective drug binding site. Elife. 2022 Jul 20;11:e74040. doi: 10.7554/eLife.74040.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.