Peptide Information

General Information of This Peptide
Peptide ID
BTDP006047
Peptide Name
HwTx-I
Symonym
Huwentoxin-1; Huwentoxin-I
Species
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Uniprot Name
TXH1_CYRSC
Alphafold ID
P56676
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1QK6
Sequence
MRASMFLALAGLVLLFVVCYASESEEKEFPRELLFKFFAVDDFKGEERACKGVFDACTPG
KNECCPNRVCSDKHKWCKWKL
   Click to Show/Hide
Sequence Length
81
Mass (Da)
9319
Signal Sequence
MRASMFLALAGLVLLFVVCYA
   Click to Show/Hide
Sequence Removed Signal Peptide
SESEEKEFPRELLFKFFAVDDFKGEERACKGVFDACTPGKNECCPNRVCSDKHKWCKWKL
   Click to Show/Hide
Disulfide Bond
50-65;57-70;64-77
PDB ID
1QK6
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schmidti
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
25.1 - 630 nM
 . . [1- 12]
 Target Info    tetrodotoxin (TTX)-sensitive sodium channel IC50
55 nM
 . . [1- 12]
 Target Info    Cav2.2 IC50
100 nM
 . . [1- 12]
References
Ref 1 cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena. Toxicon. 2003 Dec;42(7):715-23. doi: 10.1016/j.toxicon.2003.08.007.
Ref 2 Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena. Toxicon. 1993 Aug;31(8):969-78. doi: 10.1016/0041-0101(93)90256-i.
Ref 3 Assignment of the three disulfide bridges of huwentoxin-I, a neurotoxin from the spider selenocosmia huwena. J Protein Chem. 1993 Dec;12(6):735-40. doi: 10.1007/BF01024931.
Ref 4 Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena. Toxicon. 1997 Jan;35(1):39-45. doi: 10.1016/s0041-0101(96)00072-4.
Ref 5 [Chemical synthesis and characterization of R20A-HWTX-I, a mutant of huwentoxin-I with single residue replacement]. Sheng Wu Gong Cheng Xue Bao. 2000 Jul;16(4):490-4.
Ref 6 The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena. Toxicon. 2000 Sep;38(9):1237-46. doi: 10.1016/s0041-0101(99)00224-x.
Ref 7 The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study. Toxicon. 2001 Apr;39(4):491-8. doi: 10.1016/s0041-0101(00)00150-1.
Ref 8 Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats. Toxicon. 2005 Jan;45(1):15-20. doi: 10.1016/j.toxicon.2004.08.018.
Ref 9 The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun. 2007 Jun 8;357(3):579-83. doi: 10.1016/j.bbrc.2007.02.168. Epub 2007 Apr 9.
Ref 10 Functional expression of spider neurotoxic peptide huwentoxin-I in E. coli. PLoS One. 2011;6(6):e21608. doi: 10.1371/journal.pone.0021608. Epub 2011 Jun 23.
Ref 11 Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel). 2019 Jun 21;11(6):367. doi: 10.3390/toxins11060367.
Ref 12 Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution. J Protein Chem. 1997 Aug;16(6):565-74. doi: 10.1023/a:1026314722607.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.