Peptide Information

General Information of This Peptide
Peptide ID
BTDP003107
Peptide Name
Mu-theraphotoxin-Hhn1b 1
Symonym
Hainantoxin-4; Hainantoxin-IV; Peptide F8-18.88
Species
Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Uniprot Name
H4A01_CYRHA
Alphafold ID
D2Y232
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1NIY
Sequence
MKASMFLALAGLALLFVVCYASESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNP
SNDQCCKSSNLVCSRKHRWCKYEIGK
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Sequence Length
86
Mass (Da)
9505
Signal Sequence
MKASMFLALAGLALLFVVCYA
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Sequence Removed Signal Peptide
SESEEKEFSNELLSSVLAVDDNSKGEERECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCK
YEIGK
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Disulfide Bond
51-66;58-73;65-80
PDB ID
1NIY , 1RYG , 1RYV
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Haplopelma
Species: Haplopelma hainanum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 IC50
22.4 nM
 . . [1- 8]
 Target Info    tetrodotoxin (TTX)-sensitive sodium channel IC50
44.6 nM
 . . [1- 8]
 Target Info    Nav1.7 IC50
48.9 nM
 . . [1- 8]
 Target Info    Nav1.6 IC50
50.1 nM
 . . [1- 8]
References
Ref 1 Molecular diversification of peptide toxins from the tarantula Haplopelma hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses. J Proteome Res. 2010 May 7;9(5):2550-64. doi: 10.1021/pr1000016.
Ref 2 Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana. Cell Mol Life Sci. 2003 May;60(5):972-8. doi: 10.1007/s00018-003-2354-x.
Ref 3 Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol. 2003 Sep 5;477(1):1-7. doi: 10.1016/s0014-2999(03)02190-3.
Ref 4 Inhibition of sodium channels in rat dorsal root ganglion neurons by Hainantoxin-IV, a novel spider toxin. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Jan;35(1):82-5.
Ref 5 Synthesis and oxidative refolding of hainantoxin-IV. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jul;34(4):516-9.
Ref 6 [Solid-phase synthesis and biological characterization of S12A-HNTX-IV and R29A-HNTX-IV: two mutants of hainantoxin-IV]. Sheng Wu Gong Cheng Xue Bao. 2005 Jan;21(1):92-6.
Ref 7 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 8 Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers. J Biol Chem. 2004 Sep 3;279(36):37734-40. doi: 10.1074/jbc.M405765200. Epub 2004 Jun 16.
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