Peptide Information

General Information of This Peptide
Peptide ID
BTDP006619
Peptide Name
Beta-theraphotoxin-Ps1a
Symonym
PaurTx-III; Phrixotoxin-3
Species
Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Uniprot Name
TX3_PARSR
Alphafold ID
P84510
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 5WE3
Sequence
DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQI
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Sequence Length
34
Mass (Da)
4066
Sequence Removed Signal Peptide
DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQI
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Disulfide Bond
2-17;9-23;16-30
PDB ID
5WE3
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Paraphysa
Species: Paraphysa scrofa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.2 IC50
0.6 - 0.7 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 IC50
20 - 610 nM
 . . [1], [2], [3]
 Target Info    Nav1.8 IC50
20 - 610 nM
 . . [1], [2], [3]
 Target Info    Nav1.4 IC50
20 - 610 nM
 . . [1], [2], [3]
 Target Info    Nav1.5 IC50
20 - 610 nM
 . . [1], [2], [3]
 Target Info    Nav1.7 IC50
20 - 610 nM
 . . [1], [2], [3]
References
Ref 1 Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol. 2006 Feb;69(2):419-29. doi: 10.1124/mol.105.015941. Epub 2005 Nov 2.
Ref 2 Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.
Ref 3 Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins. Toxins (Basel). 2017 Aug 12;9(8):248. doi: 10.3390/toxins9080248.
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