General Information of This Target
Target ID
BTDT10266
Target Name
Sodium channel protein type 5 subunit alpha
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu-conotoxin GVIIJ Dissociation constant
207 μM
[1- 5]
 Toxin Info    Venom peptide Sh41 Effect . [6]
 Toxin Info    Venom peptide Sh42 Effect . [6]
 Toxin Info    Mu-conotoxin BuIIIC Inhibition rate . [7], [8]
 Toxin Info    Mu-sparatoxin-Hv2 Inhibition rate . [9]
 Toxin Info    Toxin Acra3 Inhibition rate . [10], [11]
 Toxin Info    Beta-mammal toxin Css2 Inhibition rate . [12- 21]
 Toxin Info    Toxin Aah4 Inhibition rate . [22], [23], [24], [25]
 Toxin Info    Neurotoxic enhancer CSTX-13 Inhibition rate . [26], [27], [28], [29]
 Toxin Info    Potassium channel toxin alpha-KTx 1.16 Inhibition rate . [30], [31]
 Toxin Info    Potassium channel toxin alpha-KTx 1.17 Inhibition rate . [30], [31]
 Toxin Info    Potassium channel toxin alpha-KTx 23.1 Inhibition rate . [32], [33]
 Toxin Info    Delta-theraphotoxin-Hm1a Inhibition rate . [34], [35], [36], [37]
 Toxin Info    Omega toxin Ap5 Inhibition rate
4.2 %
[38]
 Toxin Info    Omega-theraphotoxin-Pm1a Inhibition rate
39 %
[39], [40]
 Toxin Info    Beta-mammal/insect toxin To1 Inhibition rate
46.7 %
[41- 45]
 Toxin Info    Delta-buthitoxin-Hj1a Effective concentration 50
9.2 nM
[46]
 Toxin Info    Delta-actitoxin-Avd1c Effective concentration 50
49.05 nM
[47- 53]
 Toxin Info    Delta-actitoxin-Afv1b Effective concentration 50
62.5 nM
[54], [52], [53]
 Toxin Info    Delta-actitoxin-Bcg1b Effective concentration 50
103 nM
[53- 57]
 Toxin Info    Delta-buthitoxin-Hj2a Effective concentration 50
116.7 nM
[46]
 Toxin Info    Alpha-like toxin BmK M1 Effective concentration 50
195 - 500 nM
[58- 71]
 Toxin Info    Delta-actitoxin-Bcs1a Effective concentration 50
307 nM
[52- 72]
 Toxin Info    Delta-actitoxin-Bcg1d Effective concentration 50
440 nM
[53- 73]
 Toxin Info    Kappa-theraphotoxin-Cg1a 6 Effective concentration 50
1.18 μM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 3 Effective concentration 50
1.18 μM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 2 Effective concentration 50
1.18 μM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 4 Effective concentration 50
1.18 μM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 5 Effective concentration 50
1.18 μM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 Effective concentration 50
1.18 μM
[76], [75], [77]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
19 - 90 nM
[17- 96]
 Toxin Info    Beta-theraphotoxin-Ps1a IC50
20 - 610 nM
[97], [98], [99]
 Toxin Info    Beta-mammal toxin Css2 IC50
35 - 40 nM
[12- 21]
 Toxin Info    Beta/omega-theraphotoxin-Bp1a IC50
76 - 358 nM
[100]
 Toxin Info    Beta/omega-theraphotoxin-Tp1a IC50
76 - 358 nM
[78- 102]
 Toxin Info    Kappa-actitoxin-Ael2a IC50
92 nM
[53- 108]
 Toxin Info    Kappa-theraphotoxin-Cg1a 6 IC50
124 nM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 3 IC50
124 nM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 2 IC50
124 nM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 4 IC50
124 nM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 5 IC50
124 nM
[74], [75], [76], [77]
 Toxin Info    Kappa-theraphotoxin-Cg1a 1 IC50
124 nM
[76], [75], [77]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
188 - 323 nM
[97- 110]
 Toxin Info    Mu-thomitoxin-Hme1c IC50
268 nM
[111], [112]
 Toxin Info    Mu-theraphotoxin-Pspp1 IC50
710.6 nM
[92- 115]
 Toxin Info    Beta/mu-theraphotoxin-Pe1b IC50
>10 μM
[100]
 Toxin Info    Beta-theraphotoxin-Gr1b IC50
>200 μM
[92- 116]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
>3 μM
[97- 110]
 Toxin Info    Beta-theraphotoxin-Cd1a IC50
>30 μM
[110]
 Toxin Info    Beta-theraphotoxin-Cm1a IC50
>3 μM
[97- 110]
 Toxin Info    Kappa-theraphotoxin-Gr2c IC50
>40 μM
[92- 117]
 Toxin Info    Toxin GTx1-15 IC50
0.14 - >10 μM
[98- 117]
 Toxin Info    Toxin GTx1-15 IC50
0.14 - >10 μM
[89- 118]
 Toxin Info    MuO-conotoxin MfVIA IC50
0.431 - 3.9 μM
[119], [120]
 Toxin Info    Beta-theraphotoxin-Cm1b IC50
1.524 - 1.634 μM
[97- 110]
 Toxin Info    Beta/kappa-theraphotoxin-Cg2a IC50
2.3 - 2.9 μM
[74- 125]
 Toxin Info    Mu/kappa-theraphotoxin-Ap1a IC50
2.565 μM
[126]
 Toxin Info    Beta/omega-theraphotoxin-Tp2a IC50
4.6 μM
[17- 96]
 Toxin Info    Kappa-theraphotoxin-Aa1a IC50
7.316 μM
[126]
 Toxin Info    M-theraphotoxin-Gr1a IC50
7.4 - 14 μM
[98- 137]
 Toxin Info    Beta-theraphotoxin-Gr1a IC50
22 μM
[92- 138]
References
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Ref 80 ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels. Toxicon. 2007 Feb;49(2):194-201. doi: 10.1016/j.toxicon.2006.09.014. Epub 2006 Sep 27.
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Ref 83 Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. Toxicon. 2008 Sep 1;52(3):489-500. doi: 10.1016/j.toxicon.2008.06.023. Epub 2008 Jul 9.
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Ref 86 Crystallographic insights into sodium-channel modulation by the 4 subunit. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi: 10.1073/pnas.1314557110. Epub 2013 Dec 2.
Ref 87 Block of T-type calcium channels by protoxins I and II. Mol Brain. 2014 May 9;7:36. doi: 10.1186/1756-6606-7-36.
Ref 88 High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots. Int J Pept. 2015;2015:537508. doi: 10.1155/2015/537508. Epub 2015 Dec 30.
Ref 89 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
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