Peptide Information

General Information of This Peptide
Peptide ID
BTDP002579
Peptide Name
Mu-thomitoxin-Hme1c
Symonym
Neurotoxin Hm-3
Species
Heriaeus mellotteei (Crab spider) (Heriaeus oblongus)
Uniprot Name
TXHM3_HERML
Alphafold ID
C0HJK5
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 2MQU
Sequence
GCIAKNKECAWFSGEWCCGALSCKYSIKRNLKICV
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Sequence Length
35
Mass (Da)
3914
Sequence Removed Signal Peptide
GCIAKNKECAWFSGEWCCGALSCKYSIKRNLKICV
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Disulfide Bond
2-18;9-23;17-34
PDB ID
2MQU
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Thomisidae
Genus: Heriaeus
Species: Heriaeus mellotteei
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.3 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv2.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv4.2 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv11.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.8 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.3 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Cav3.3 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.4 IC50
103 nM
 . . [1], [2]
 Target Info    Nav1.5 IC50
268 nM
 . . [1], [2]
 Target Info    Para/DmNav1 IC50
555 nM
 . . [1], [2]
 Target Info    Nav1.2 IC50
1.447 μM
 . . [1], [2]
 Target Info    Nav1.6 IC50
3.504 μM
 . . [1], [2]
References
Ref 1 Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae. J Biol Chem. 2015 Jan 2;290(1):492-504. doi: 10.1074/jbc.M114.595678. Epub 2014 Oct 28.
Ref 2 Spider toxin inhibits gating pore currents underlying periodic paralysis. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4495-4500. doi: 10.1073/pnas.1720185115. Epub 2018 Apr 10.
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