Peptide Information

General Information of This Peptide
Peptide ID
BTDP008683
Peptide Name
Kappa-actitoxin-Ael2a
Symonym
Toxin APETx1
Species
Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Uniprot Name
BDS1_ANTEL
Alphafold ID
P61541
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1WQK
Sequence
GTTCYCGKTIGIYWFGTKTCPSNRGYTGSCGYFLGICCYPVD
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Sequence Length
42
Mass (Da)
4558
Sequence Removed Signal Peptide
GTTCYCGKTIGIYWFGTKTCPSNRGYTGSCGYFLGICCYPVD
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Disulfide Bond
4-37;6-30;20-38
PDB ID
1WQK , 7BWI
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anthopleura
Species: Anthopleura elegantissima
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv1.2 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv1.3 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv1.5 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv1.6 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv2.1 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv3.4 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv4.2 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv11.1 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv12.3 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv11.2 Inhibition rate .
1 μM
Modifier
 [1- 7]
 Target Info    Kv7.1 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv7.2 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv7.3 Inhibition rate .
100 nM
Modifier
 [1- 7]
 Target Info    Kv1.4 Inhibition rate
35 %
1 μM
Modifier
 [1- 7]
 Target Info    Nav1.2 IC50
31 nM
 .
Modifier
 [1- 7]
 Target Info    Kv11 IC50
34 nM
 .
Modifier
 [1- 7]
 Target Info    Kv11.1 IC50
34 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.8 IC50
92 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.3 IC50
92 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.4 IC50
92 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.5 IC50
92 nM
 .
Modifier
 [1- 7]
 Target Info    Nav1.6 IC50
92 nM
 .
Modifier
 [1- 7]
References
Ref 1 APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels. Mol Pharmacol. 2003 Jul;64(1):59-69. doi: 10.1124/mol.64.1.59.
Ref 2 Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol. 2006 May;69(5):1673-83. doi: 10.1124/mol.105.019729. Epub 2006 Feb 23.
Ref 3 APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-a-go-go- related potassium channel. Mol Pharmacol. 2007 Aug;72(2):259-68. doi: 10.1124/mol.107.035840. Epub 2007 May 1.
Ref 4 A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. 2012 Dec;26(12):5141-51. doi: 10.1096/fj.12-218479. Epub 2012 Sep 12.
Ref 5 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 6 Defensin-neurotoxin dyad in a basally branching metazoan sea anemone. FEBS J. 2017 Oct;284(19):3320-3338. doi: 10.1111/febs.14194. Epub 2017 Sep 6.
Ref 7 Solution structure of APETx1 from the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin. Proteins. 2005 May 1;59(2):380-6. doi: 10.1002/prot.20425.
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