Peptide Information

General Information of This Peptide
Peptide ID
BTDP004276
Peptide Name
Delta-actitoxin-Bcg1b
Symonym
Cangitoxin II; Cangitoxin-2; Cangitoxin-II
Species
Bunodosoma cangicum (Sea anemone)
Uniprot Name
NA1B_BUNCN
Alphafold ID
P0C7P9
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C7P9
Sequence
GVACRCDSDGPTVRGDSLSGTLWLTGGCPSGWHNCRGSGPFIGYCCKK
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Sequence Length
48
Mass (Da)
4964
Sequence Removed Signal Peptide
GVACRCDSDGPTVRGDSLSGTLWLTGGCPSGWHNCRGSGPFIGYCCKK
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Disulfide Bond
4-45;6-35;28-46
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Bunodosoma
Species: Bunodosoma cangicum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.5 Effective concentration 50
103 nM
 .
Delay Nav inactivation
 [1], [2], [3], [4]
 Target Info    Nav1.6 Effective concentration 50
133 nM
 .
Delay Nav inactivation
 [1], [2], [3], [4]
 Target Info    Nav1.1 Effective concentration 50
165 nM
 .
Delay Nav inactivation
 [1], [2], [3], [4]
References
Ref 1 Revisiting cangitoxin, a sea anemone peptide: purification and characterization of cangitoxins II and III from the venom of Bunodosoma cangicum. Toxicon. 2008 Jun 1;51(7):1303-7. doi: 10.1016/j.toxicon.2008.01.011. Epub 2008 Feb 2.
Ref 2 Characterization of selectivity and pharmacophores of type 1 sea anemone toxins by screening seven Na(v) sodium channel isoforms. Peptides. 2012 Mar;34(1):158-67. doi: 10.1016/j.peptides.2011.07.008. Epub 2011 Jul 20.
Ref 3 Actions of sea anemone type 1 neurotoxins on voltage-gated sodium channel isoforms. Toxicon. 2009 Dec 15;54(8):1102-11. doi: 10.1016/j.toxicon.2009.04.018. Epub 2009 Apr 23.
Ref 4 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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