Peptide Information

General Information of This Peptide
Peptide ID
BTDP008448
Peptide Name
Potassium channel toxin alpha-KTx 1.17
Symonym
Toxin MeKTx11-3
Species
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Uniprot Name
KAX1H_MESEU
Alphafold ID
C0HJQ7
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HJQ7
Sequence
QFTDVKCTVTKQCWPVCKKMFGRPNGKCMNGKCRCYS
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Sequence Length
37
Mass (Da)
4277
Sequence Removed Signal Peptide
QFTDVKCTVTKQCWPVCKKMFGRPNGKCMNGKCRCYS
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Disulfide Bond
7-28;13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus eupeus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.5 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv2.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv3.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv4.2 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv11.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Nav1.1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.2 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.4 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Nav1.5 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv4.1 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kv11 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Cav3.3 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv4.2 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    BgNav1 Inhibition rate .
1 μM
 . [1], [2]
 Target Info    Kv1.2 IC50
3.1 nM
 .
Blocker
 [2]
 Target Info    Kv1.2 IC50
3.1 nM
 . . [1], [2]
 Target Info    Kv1.3 IC50
78 nM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
78 nM
 . . [1], [2]
 Target Info    Kv1 IC50
130 nM
 .
Blocker
 [2]
 Target Info    Kv1 IC50
130 - 135 nM
 . . [1], [2]
 Target Info    Kv1 IC50
134.8 nM
 .
Blocker
 [1]
 Target Info    Kv1.6 IC50
910 nM
 .
Blocker
 [2]
 Target Info    Kv1.6 IC50
910 nM
 . . [1], [2]
References
Ref 1 Variability of Potassium Channel Blockers in Mesobuthus eupeus Scorpion Venom with Focus on Kv1.1: AN INTEGRATED TRANSCRIPTOMIC AND PROTEOMIC STUDY. J Biol Chem. 2015 May 8;290(19):12195-209. doi: 10.1074/jbc.M115.637611. Epub 2015 Mar 19.
Ref 2 K(V)1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity. Neuropharmacology. 2018 Dec;143:228-238. doi: 10.1016/j.neuropharm.2018.09.030. Epub 2018 Sep 22.
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