Peptide Information

General Information of This Peptide
Peptide ID
BTDP006832
Peptide Name
Delta-actitoxin-Bcg1d
Symonym
Delta-AITX-Bcg1a; Delta-AITX-Bcg1b; Delta-actitoxin-Bcg1e; Toxin Bcg 30.24
Species
Bunodosoma cangicum (Sea anemone)
Uniprot Name
NA1D_BUNCN
Alphafold ID
P86459
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P86459
Sequence
GVPCLCDSDGPSVRGNTLSGTVWVFGCPSGWHICTSDGPTIGSCCKK
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Sequence Length
47
Mass (Da)
4786
Sequence Removed Signal Peptide
GVPCLCDSDGPSVRGNTLSGTVWVFGCPSGWHICTSDGPTIGSCCKK
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Disulfide Bond
4-44;6-34;27-45
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Bunodosoma
Species: Bunodosoma cangicum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.5 Effective concentration 50
440 nM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.1 Effective concentration 50
453 nM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.6 Effective concentration 50
1.74 μM
 .
Delay Nav inactivation
 [1], [2], [3]
References
Ref 1 Characterization of selectivity and pharmacophores of type 1 sea anemone toxins by screening seven Na(v) sodium channel isoforms. Peptides. 2012 Mar;34(1):158-67. doi: 10.1016/j.peptides.2011.07.008. Epub 2011 Jul 20.
Ref 2 Proteomics of the neurotoxic fraction from the sea anemone Bunodosoma cangicum venom: Novel peptides belonging to new classes of toxins. Comp Biochem Physiol Part D Genomics Proteomics. 2008 Sep;3(3):219-25. doi: 10.1016/j.cbd.2008.04.002. Epub 2008 Apr 26.
Ref 3 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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