Peptide Information

General Information of This Peptide
Peptide ID
BTDP006579
Peptide Name
Neurotoxic enhancer CSTX-13
Symonym
U2-ctenitoxin-Cs1a
Species
Cupiennius salei (American wandering spider)
Uniprot Name
TXC13_CUPSA
Alphafold ID
P83919
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P83919
Sequence
MKVLVIFAVLSLVIFSNCSAETDEDFFGEESFEADDIIPFIAKEQVRSDCTLRNHDCTDD
RHSCCRSKMFKDVCTCFYPSQRSETARAKKELCTCQQPKHLKYIEKGLQKAKDYATG
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Sequence Length
117
Mass (Da)
13404
Signal Sequence
MKVLVIFAVLSLVIFSNCSA
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Sequence Removed Signal Peptide
ETDEDFFGEESFEADDIIPFIAKEQVRSDCTLRNHDCTDDRHSCCRSKMFKDVCTCFYPS
QRSETARAKKELCTCQQPKHLKYIEKGLQKAKDYATG
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Disulfide Bond
50-65;57-74;64-95;76-93
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Ctenidae
Genus: Cupiennius
Species: Cupiennius salei
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    ERG Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Para/DmNav1 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv1.1 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv1.2 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv1.3 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv1.4 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv1.5 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv1.6 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv2.1 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv3.1 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv4.2 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Kv4.3 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Shaker-IR Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Nav1.2 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Nav1.4 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Nav1.5 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Nav1.6 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
 Target Info    Cav3.3 Inhibition rate .
500 nM
 . [1], [2], [3], [4]
References
Ref 1 The Dual Prey-Inactivation Strategy of Spiders-In-Depth Venomic Analysis of Cupiennius salei. Toxins (Basel). 2019 Mar 19;11(3):167. doi: 10.3390/toxins11030167.
Ref 2 CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae). Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11251-6. doi: 10.1073/pnas.0402226101. Epub 2004 Jul 22.
Ref 3 Spider venom: enhancement of venom efficacy mediated by different synergistic strategies in Cupiennius salei. J Exp Biol. 2005 Jun;208(Pt 11):2115-21. doi: 10.1242/jeb.01594.
Ref 4 Neurotoxin Merging: A Strategy Deployed by the Venom of the Spider Cupiennius salei to Potentiate Toxicity on Insects. Toxins (Basel). 2020 Apr 12;12(4):250. doi: 10.3390/toxins12040250.
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