Peptide Information

General Information of This Peptide
Peptide ID
BTDP005714
Peptide Name
Delta-actitoxin-Afv1b
Symonym
AFT-II
Species
Anthopleura fuscoviridis (Sea anemone)
Uniprot Name
NA12_ANTFU
Alphafold ID
P10454
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P10454
Sequence
GGVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKAHGPTIGWCCKQ
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Sequence Length
48
Mass (Da)
4941
Sequence Removed Signal Peptide
GGVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKAHGPTIGWCCKQ
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Disulfide Bond
5-45;7-35;28-46
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anthopleura
Species: Anthopleura fuscoviridis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Effective concentration 50
30.62 nM
 . . [1], [2], [3]
 Target Info    Nav1.5 Effective concentration 50
62.5 nM
 . . [1], [2], [3]
 Target Info    Nav1.6 Effective concentration 50
300 nM
 . . [1], [2], [3]
 Target Info    Nav1.1 Effective concentration 50
390.55 nM
 . . [1], [2], [3]
 Target Info    Nav1.3 Effective concentration 50
459.36 nM
 . . [1], [2], [3]
 Target Info    Nav1.2 Effective concentration 50
1.998 μM
 . . [1], [2], [3]
References
Ref 1 Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis. Toxicon. 1987;25(2):211-9. doi: 10.1016/0041-0101(87)90243-1.
Ref 2 Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop. J Biol Chem. 2004 Aug 6;279(32):33323-35. doi: 10.1074/jbc.M404344200. Epub 2004 May 28.
Ref 3 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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