Peptide Information

General Information of This Peptide
Peptide ID
BTDP007537
Peptide Name
Delta-actitoxin-Bcs1a
Symonym
Bc-III; Major neurotoxin BcIII
Species
Bunodosoma caissarum (Sea anemone)
Uniprot Name
NA13_BUNCI
Alphafold ID
Q7M425
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: Q7M425
Sequence
GVACRCDSDGPTSRGNTLTGTLWLTGGCPSGWHNCRGSGPFIGYCCKK
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Sequence Length
48
Mass (Da)
4979
Sequence Removed Signal Peptide
GVACRCDSDGPTSRGNTLTGTLWLTGGCPSGWHNCRGSGPFIGYCCKK
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Disulfide Bond
4-45;6-35;28-46
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Bunodosoma
Species: Bunodosoma caissarum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.1 Effective concentration 50
˜300 nM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.6 Effective concentration 50
˜900 nM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.5 Effective concentration 50
307 nM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.4 Effective concentration 50
820.84 nM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.2 Effective concentration 50
1.44917 μM
 .
Delay Nav inactivation
 [1], [2], [3]
 Target Info    Nav1.3 Effective concentration 50
1.45842 μM
 .
Delay Nav inactivation
 [1], [2], [3]
References
Ref 1 Characterization of peptides in sea anemone venom collected by a novel procedure. Toxicon. 1993 Jul;31(7):853-64. doi: 10.1016/0041-0101(93)90220-d.
Ref 2 Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop. J Biol Chem. 2004 Aug 6;279(32):33323-35. doi: 10.1074/jbc.M404344200. Epub 2004 May 28.
Ref 3 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
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